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SciTechStory tracks science and technology through the filter of "Impact Areas" - those areas which are likely to have the most impact on (human) life.

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New proteomics: Fat isn’t inactive

Most people think of fat as stuff that just sits there – like the pendulous beer belly or the not so cute love handles. Scientists too have long thought of fat…and fat cells…as simply repositories of lipids (fats), which are storehouse material for energy that can be used by the body. Recent work, however, is showing fat cells to be more like an active organ of the body. More »

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Posted in News: Proteomics | Tagged , , , , , , , , | Leave a comment

Facial recognition software: Caught infrared handed

Every advance in the ability to recognize faces in digital images adds to the saying, “You can run, but you cannot hide.” This applies not only to criminals, terrorists, and local thugs but also to political dissidents, profiled minorities, and business competitors – it all depends on the circumstances. The technical circumstances of facial recognition have always been difficult. Put a face in a studio with optimal lighting and the camera/software combination will get recognition right almost every time. Put the same face in a brightly lit street full of motion and shadows, and the recognition rate goes toward nil.

The CheckPoint.S system developed by the firm Omniperception (Surrey, UK) reckons on natural lighting being forever difficult to use for facial recognition. Instead, the new system uses its own lighting – near-infrared light emitted from the camera. Infrared light is invisible to the human eye and is somewhat less complicated to analyze (limited bandwidth) for specific biometric features. More »

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Posted in News: Sensor Technology | Tagged , , , , , , | Leave a comment

A new field for medicine: Genetic risk intervention

If you’ve heard anything about personal genome testing, it’s that such tests can sometimes reveal people are carriers of genetic mutations that increase the risk of certain diseases. There are many examples with more added each year, such as the BRCA1/BRCA2 genes associated with breast and ovarian cancer. If you’re a woman whose genome has tested positive for a mutated BRCA1 gene, the questions are: What does this mean? What can I do about it?

Such questions are launching a new field of medicine: genetic risk intervention (or prophylactic risk reduction). If you’re a woman identified with a mutated BRCA1/2 gene, then studies show that over a lifetime you are 56% – 80% more likely to develop breast cancer than women without the gene. These are not long odds. Many women would prefer (or insist) that something be done. That something could be mastectomy (removal of the breasts) or a salpingo-oophorectomy (removal of the fallopian tubes and ovaries). Both are serious procedures with obvious personal implications. Nevertheless, some women are going to see them as justified against the odds of dying from cancer. More »

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Posted in Impact: Major Disease Cures | Tagged , , , , , , , , | 1 Comment

Promised cures that stay on the horizon

In this age of hyperbole and disingenuous narrative, it’s important to have keen and skeptical appraisal. This is true even (or especially) when it comes to life-saving cures and the promises of the end to various terrible afflictions. Part of the reason for skepticism is simply to manage expectations. The people developing or marketing their cures (whether in research stage or as products) have a secondary interest in being realistic; you, on the other hand have a primary interest in not expecting things that are not likely to happen. Like curing cancer next week, or reversing grandfather’s Alzheimer disease. In this regard, here are a blog posting and an article that speak to why we are being promised so many medical miracles that don’t seem to happen. They help set a framework around medical ‘breakthroughs’ and science in general, that you may find useful: More »

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A spate of exoplanets

The search for planets outside the solar system that could (repeat, could) harbor life goes on at a faster pace. The big gun is the Kepler Space Telescope, which in part was designed to look for terrestrial-like planets, and is now coming into the full stream of operation. Kepler scientists reported on Thursday (August 26, 2010) the first indication of a planet only 1.5 times the diameter of Earth in a solar system with a Sun-like star (now known as Kepler-9) about 2,000 light years away. The word ‘indication’ is important, since the planet and its characteristics are still in the confirmation stage. It would be the first Earth-size(ish) planet discovered by the Kepler team.

More definitely, the Kepler team announced the discovery of two Saturn-size planets in the same Kepler-9 solar system.

Kepler has already amassed about700 ‘candidate’ planets, with every expectation that there are many more to come.

Earlier in the week a European team working with the HARPS (High Accuracy Radial Velocity Planet Searcher) equipment at the European Southern Observatory in Chile reported discovery of an even smaller planet with a mass approximately 1.4 times that of Earth, orbiting a star (only) 127 light-years away. More spectacularly, this was just one of seven planets in a solar system, HD10180, located in the constellation Hydrus. Two of the planets, including the Earth-size(ish) planet still need confirmation, although there is a high probability of the finding. More »

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Posted in News: Exolife | Tagged , , , , , , , , , | Leave a comment

Hygroelectricity – hokum or an alternative source of energy?

There’s a nugget of scientific newness in the presentation at the national meeting of the Amercian Chemical Society of findings by Fernando Galembeck and colleagues at the University of Campinas (Brazil). For decades it has been accepted theory that water vapor in clouds is electrically neutral, even when it comes into contact with charged particles of dust. The evidence provided by Galembeck’s laboratory experiments indicates that water vapor does hold a charge. Using particles of silica and aluminum phosphate in a very humid atmosphere (humid = more water vapor), it appears that the water vapor can hold an electrical charge and pass it to the particles. They dubbed this form of charge hygroelectricity, or humidity electricity. More »

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No muscle, no Mars

After feeding upon the thrills of Star Trek, Star Wars, Avatar and their ilk, we (that is, people of the entertainment soaked portion of the world) are conditioned to be optimistic about human beings in space. There’s also the reality of landing on the Moon, the International Space Station, and the inspiring history of astronauts and cosmonauts. We’re also at least dimly aware that occupying space can be unexciting, routine – a grind. What most people don’t know, including many people very interested in human exploration of space, is that there are ‘show stoppers,’ ‘elephants in the room,’ – some very real problems with sustaining human life in outer space. If these problems aren’t overcome, there will be no ‘colonization of space’ or even missions to Mars.

It’s been known for quite some time, at least back to the early days of cosmonauts and astronauts in the 1960’s and 70’s, that there are two huge physical problems with extended living in space: Loss of bone and muscle mass due to weightlessness, and cumulative exposure to radiation, especially solar and cosmic radiation. A third problem generally ignored by Americans in space (NASA) but somewhat explored by the old Soviet space program is psychological: The negative effects of living in extreme close quarters for months on end in a very risky and hostile environment.

There have been many studies of all the problems (just throw any phrase like ‘muscle loss in space’ into a search engine), so it’s disconcerting to see a news release like “Astronauts muscles waste in space” (Marquette University, Wisconsin USA) that goes on about a new study as if it were something of a revelation. Worse yet is the tendency of credulous media to echo the revelation angle without the slightest effort to put it into context or weigh its significance. More »

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Stretch graphene, europium titanate – get interesting results

Forgive the pun, but a new way to get unusual behavior from graphene or europium titanate is a stretch. Literally a stretch, as in taking the material (which is produced in sheets) and stretching it. Stretching is a basic physical technique but applied to unusual materials it sometimes produces unexpected results. In this case two studies, one by Lawrence Berkeley Labs (California, USA) with graphene, and another by researchers at Cornell University (New York, USA) with europium titanate have shown that not only are the properties of the material radically changed, but also their potential application. More »

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Posted in News: Nanotechnology | Tagged , , , , , , , , , , | Leave a comment

Light through a galactic lens: Good news, bad news of dark energy

The good news is that thanks to research by an international group of scientists and published in the August 20, 2010 issue of Science [Cosmological Constraints from Strong Gravitational Lensing in Clusters of Galaxies] we have a much more precise idea of the amount of dark energy in the universe and a fix on the geometry of the universe as well. The bad news is according to the study, some previous notions are probably right: The universe is flat and will expand forever, leading to terminal entropy. (Translation: In some 10100 years, give or take, the universe will be so expanded that there will be no more energy for heat, in short, the death of the universe.)

This is not a new idea; the precursors go back to the 1850’s and discussions about the laws of thermodynamics. The total entropy (heat-death) of the universe has always been one of the ‘logical’ options and is often contrasted with the infinitely recurring universe (sort of Big-Bang cycle). There are other cosmological variants about the fate of the universe. However, new evidence that provides confirmation of one variant or another is important – if not necessarily conclusive. More »

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Posted in Impact: Cosmology | Tagged , , , , , , , , | Leave a comment

A form of muscular dystrophy depends on ‘junk’ DNA

Back in February of this year (2010) a study in Nature reported on finding a segment of human DNA, one of the areas in the so-called ‘junk genes,’ that contributed to a form of coronary artery disease. [SciTechStory: Junk DNA that actually does something] Now there is another study, in the magazine Science [A Unifying Genetic Model for Facioscapulohumeral Muscular Dystrophy] by a large international team of researchers (France, Netherlands, Spain, USA), that discovered another instance where a ‘junk gene’ plays a major role in a disease, in this case muscular dystrophy.

First and foremost, this is an important finding for the study and treatment of specifically facioscapulohumeral muscular dystrophy or FSHD, one of the most common forms, as it reveals a particular gene, repeated at the end of chromosome 4 (4q35), is the key to triggering onset of FSHD.

It is also, as an article in the New York Times puts it (August 19, 2010: Reanimated ‘Junk’ DNA is Found to Cause Disease), the surprising activation of a ‘dead’ gene. Dead in the sense that the areas of junk DNA are non-coding, meaning they’re not used to create protein.

Actually, not so surprising. The areas of ‘junk DNA’ comprise about 98% of the human genome, which in itself is a curiously high percentage. It shouldn’t be surprising that with all that material, from time to time it is discovered that – lo and behold – one of the junk genes does something. More »

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Posted in Impact: DNA Decoding | Tagged , , , , , , , , | Leave a comment

Observing dynamic molecular biology with PAINT

Scientific instrumentation has the ability to turn theory into observed fact. This is, of course, a very important part of the advance of scientific knowledge. Without the microscope, we might know nothing of the world beyond our eyesight, or at best, we could only guess about it. This sort of progress (and it is certainly difficult to say this isn’t Progress) goes on all the time; it’s one of the hallmarks of the relationship between science and technology. A recent example is the development of microscopy to observe the workings of living cells at the molecular level.

Biologists know that, for example, the way protein molecules fold (their configuration) is crucial to the chemical pathways of many cell processes. In theory, certain folding is necessary, but no one has seen the folding take place because scientists haven’t had the equipment to observe it. Technically, achieving this kind of instrumentation is difficult. For one thing, the scale is very small, nanoscale (billionths of a meter), and only the most powerful of microscope technology can achieve this scale. For another, most microscope technology powerful enough to make the observations at the molecular level are also destructive of living processes.

One of the newest approaches, developed by Laurent Cogent and colleagues at the University of Bordeaux (France) and published in Biophysical Journal, is called points accumulation for imaging in nanoscale topography (or PAINT) microscopy. In a sense the technique works like a super high-speed camera (driven by software) that acquires images at the rate of 50 milliseconds for about 5,000 consecutive frames at the resolution of roughly 50 nanometers. More »

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Biosensors: A sensor/probe inside a single cell

Can scientists put sensors inside single cells? The answer used to be, yes, but not without damaging the cell (a little or a lot). Cells, human or otherwise, are very small. Human cells vary from nerve cells at about 10 microns (that’s millionths of a meter) to 50 microns for heart cells (still very small). Current probes run about 5 microns, small enough to penetrate most cells but obviously with small cells like neurons (5 microns into 10 microns) not without overwhelming the cell. Not surprisingly, scientists at Harvard University turned to nanotechnology for a solution. Charles M. Lieber, professor of chemistry and his team have worked on various aspects of nanotechnology for years. In a paper published in the journal Science August 13, 2010 as Three-Dimensional, Flexible Nanoscale Field-Effect Transistors as Localized Bioprobes they describe the development of a nanowire device that functions as a V-shaped transistor small enough to probe the interior of a cell without damage. More »

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The advance of swarm intelligence

Swarm intelligence – where the behavior of many semi-intelligent individuals becomes intelligent in collective activity – think of ants or bees, has been an area of study for some time but on no perceivable schedule or cycle seems to appear in the popular media as a matter of considerable importance. I thought of this while reading a new example, an article in The Economist, Riders on a swarm. The central point of the article is that swarm intelligence points to ways in which human intelligence may work, and as such may be useful to computer scientists developing artificial intelligence. They do need the help, as the article says, because development of artificial intelligence (at least at the human level) has so far been a bust.

It turns out that research on swarm intelligence has many potential applications that are pursued by a diverse set of interests including the military, space agencies, robotics companies, and nanotechnology research. Why? More »

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Transposons and the dynamic genome

Most people know that DNA can mutate – genetic sequences can be altered and carried on by reproduction. Less well known is that DNA also changes, in a sense mutates, during the life cycle of a normal cell – with or without reproduction. There are sequences of DNA that can move about to different positions within the genome of a single cell in a process called transposition. These sequences are called transposons and a new study by the Johns Hopkins University School of Medicine released in the June 24 issue of the journal Cell [Mobile Interspersed Repeats Are Major Structural Variants in the Human Genome] indicates that are a lot more of them and they are more active than previously thought. More »

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NDM-1: Not a ‘superbug’ but possibly worse

The idea – and reality – that bacteria can develop immunity to a broad spectrum of treatment is not new. Drug resistant strains of tuberculosis have been a problem for decades. Doctors worry that over-treatment with antibiotics is leading to the evolution of the drug resistant strains of many diseases. The worst case is the so-called ‘superbug,’ the disease for which no antibiotic is effective. The word superbug is not exactly misleading, but it lumps too many variables into a scare-mongering package. Now there are new specific instances of untreatable bacterial disease, including one fatality. More »

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Posted in News: Pandemics | Tagged , , , , , , , | 2 Comments

The PETE process: Solar heat + light = more electricity

Using the light from the Sun to generate electricity is commonplace. So is generating electricity through heat, as in steam turbines. Combining solar light and solar heat to generate energy is an obvious juxtaposition, but until now undemonstrated as a feasible technology. That’s why the proof of concept testing on a concept called PETE (photon enhanced thermionic emission) performed by scientists at Stanford University (California, USA), and published in Nature Materials August 1 [Photon-enhanced thermionic emission for solar concentrator systems, payment or subscription required] sets up an interesting and potentially important new track for alternative sources of energy. More »

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New Report: The Construction Nanomaterials Revolution

Of the many ongoing technology developments, it’s arguable that nanotechnology will have the most immediate, visible, and continuing impact. Nano-this and nano-that have already sprung up in the English vocabulary like mushrooms after rain and marketing-speak has long since incorporated the benefits of NEW: With Nano-whatever. Barely a week goes by without an announcement of some advancement in nanotechnology and the majority of these announcements are couched in their relationship to a practical application. So it should not be surprising even to people with only passing knowledge of nanotechnology that one of the areas about to be changed (if not revolutionized) is the construction industry – in particular the enhancement of construction materials by the incorporation of manufactured nanomaterials (MNMs).

Whether you’re following the development or just interested in the possible impact of nanotechnology, a new report published by the American Chemical Society (ACS) in the journal ACS Nano, titled Nanomaterials in the Construction Industry: A Review of Their Applications and Environmental Health and Safety Considerations is a comprehensive look at the future of nanotechnology in the materials used by the construction industry AND their potential impact on health and the environment. A lengthy abstract is available at the above URL; the full text of the report requires subscription or purchase. More »

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Stress test for computers: New sorting records

In the old days people used index cards to sort information such as names or addresses by alphabetical order. Have you ever sorted a thousand cards? Try sorting the information on 210 DVDs or 1,422 CDs – that’s how much information is contained in a terabyte (1000 gigabytes or one million megabytes). Obviously this is something computers do better than people, much better. How much better? The new world record for sorting a terabyte of data, recently achieved by a team from the University of California San Diego, is sixty seconds – one minute flat. The same team also tied for another sorting record, that of processing one trillion data records in 172 minutes (i.e. a trillion pieces of information sorted in less than three hours).

Sorting is so important to the business of computing that it’s like a competitive sport. An independent group of computer scientists operates the Sort Benchmark Organization and several sorting contests. There are several contests because sorting like so much in computing isn’t simple. For one thing the organization makes a big distinction between sorting done in specially constructed systems, where the hardware, operating system, and application software are completely integrated, tuned, and optimized for a particular kind of sorting. This is called the Indy class of sorting. Then there is the Daytona class, which requires sorting be done only on machines and operating systems that are normally found in data centers – ‘real world’ environments. More »

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Posted in Impact: Computer Power | Tagged , , , , , , | Leave a comment

Ranger the robot pushes perambulation record

ranger
Ranger walking into the record books…………….credit: Cornell University

Ranger looks rather spindly, uses four thin legs, which act like three legs moving similar to someone on crutches; but it is a champion (at least for now). On July 6 Ranger set the long-distance record for untethered walking – 14.3 miles (23 kilometers) on a single charge of its batteries. Ranger is the creation of Professor Andy Ruina and robotic engineering students at Cornell University (New York, USA) and was put through its paces at the Barton Hall indoor track. Ranger completed 108.5 turns around the 212 meter track in about 11 hours, guided only by humans with a typical controller used for toys. The new record – and this is an ongoing competition – surpassed the mark of 12.8 miles (20.6 kilometers) set by Big Dog of Boston Dynamics (a private corporation spin-off of MIT). Although it too has four legs, Big Dog uses a totally different design approach, which is squat to the ground and bulky.

Robotic designers around the world continue to deal with the challenge of locomotion, both in terms of how it is done (wheels, legs, treads) and efficiency (how long and how far can it go without re-fueling). Some designs also deal with autonomic guidance, where the robot sees and navigates on its own. Taken together this research not only aims to build robots with extended capability for motion, but also in the process discover how it is that animals (and humans) have achieved their ability to move at relatively high levels of efficiency.

[Source: Cornell University]

Research Spectrum

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India announces world’s least expensive computer, again

The government of India announced on July 23 that it has developed a prototype $35 tablet-style computer for use in Indian schools beginning in 2011. This would be the least expensive computer in the world. (Queues for purchase will form on the west bank of the Yamuna River just north of the New Delhi ring road.) Skeptics have noted that the Indian government announced a $10 computer last year, which turned out to be complete vaporware. This time, the announcement comes from the Minister of Human Resource Development, Kapil Sabil, who held the prototype in his hand. The tablet computer was designed by two of India’s leading schools, the Indian Institute of Technology in Delhi and the Indian Institute of Science in Bengaluroo (Bangalore). It uses ‘off the shelf’ components except for the custom motherboard and features 2 Gigabyte memory card storage, touch sensitive screen, a USB connector, and a version of the Linux operating system with Open Office software. More »

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Posted in News: Computer Power | Tagged , , , , , , , | 1 Comment

Graphene oxide: Nanotechnology with an eco-friendly end

It isn’t often (like almost never) that a new technology with potential impact on the environment comes with its own natural solution. According to two papers published by scientists from Rice University (Texas, USA), this is the case with graphene oxide.

Graphene, a form of carbon, can be simply described as a form of graphite (as in pencil lead) that exists in sheets or layers one atom thick. It has an incredible number of potential applications. For example, it can be used in making plastics (polymers), ceramics, reinforced metals, electronics, drug-delivery devices, hydrogen storage, and with modification as a semiconductor. However, most of these applications require mass production to be significant.

One of the principle forms of graphene is graphene oxide, which is mostly carbon with oxygen and a few atoms of hydrogen. Graphene oxide is an insulator, meaning it doesn’t conduct electricity, but has many other properties that it shares with basic graphene. It is also potentially used as an intermediate form in the process of making graphene. More »

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New study: Potential U.S. water shortage by 2050

Water Shortage
Water index (short of demand) 2050, United States…Credit: NRDC

In a study conducted by Tetra Tech, Inc. for the National Resources Defense Council (NRDC), a major U.S. conservation group, more than 1,100 counties in the United States will face water shortages by 2050. Over 400 counties will experience extreme water shortage conditions. These findings are based on the analysis of trends in growth of water use (especially population and energy demand) and the availability of renewable water supply given average results from sixteen established climate models. (These models reflect the conditions of a changing climate.) The study is not making predictions of where water shortages will occur, but given an unchanged usage pattern it does highlight those areas where water shortage is most likely to occur.

The Tetra Tech report develops a new water supply sustainability index. The risk to water sustainability is based on the following criteria: (1) projected water demand as a share of available precipitation; (2) groundwater use as a share of projected available precipitation; (3) susceptibility to drought; (4) projected increase in freshwater withdrawals; and (5) projected increase in summer water deficit.

[Source: NRDC]

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New Russian spaceport: Vostochny Cosmodrome

Some space facilities are built in secret (military) or with little fanfare perhaps because they’re not very ambitious. But when the Russian Prime Minister (V. Putin) announces the building of a new $800 million spaceport – or cosmodrome, it’s clearly intended to be very public. This fits with the avowed use for a new ‘civilian’ (read: commercial) space facility. The Russians have done their market research: They frequently get business dropped by other space agencies (e.g. American shuttle and ISS support) and there is a need for a somewhat smaller but expert and efficient launch site for all kinds of commercial space activity. The Russians are developing a track-record in this area. It’s also relatively profitable. More »

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A new role for a key cell protein

We know from our experience, intuition, and scads of studies that the body reacts to stress – often negatively. For the most part, long term stress is harmful. There are many muscular, neurological, vascular, and digestive reactions (to name a few) that if not significantly relieved by some point, turn toward physical degeneration and disease – ulcers, neuroses, arthritis, heart attacks – among many. We are familiar with the causes, we know most of the symptoms, and for the most part we know what organs are involved. What we don’t know all that much about in useful detail are the molecular, cellular, and genetic pathways that are involved in stress reactions. It’s an area where research has been underway for only a decade or three (and sometimes much less). So it’s not surprising that with some regularity discoveries are made that reveal wholly unknown processes.

A good example is the recently published research from a team led by scientists at the University of Pennsylvania School of Medicine (USA) in Science Express [Signaling Kinase AMPK Activates Stress-Promoted Transcription via Histone H2B Phosphorylation]. Their work shows that the master regulator of cell energy production, AMP-activated protein kinase or AMPK, is also responsible for interacting with cell DNA under conditions of stress to increase, slow-down, or even stop cell growth. The energy role of AMPK has been known for decades; the epigenetic role was unknown. More »

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Posted in Impact: Proteomics | Tagged , , , , , , , , , , | Leave a comment

microRNA: A cellular communicator

Discovered only about fifteen years ago, research on the non-coding variant of RNA called microRNA (or miRNA) continues to expand its role. New work by Chen-Yu Zhang and colleagues at five Chinese institutions has identified miRNA as an important cell-to-cell and cell-to-organ communication mechanism, one that is more versatile than the traditional notion of cellular communication via hormones or antigens. The discovery opens a research window on a potentially very important ‘two-way’ chemical communication system within living organisms that permits ‘broadcast’ and ‘feedback’ of miRNAs with multiple genes as targets. More »

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