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Stem cell injection improves aging cells in mice

“The provocative findings urge further research,” said Dr. Niedernhofer, one of the senior investigators on a University of Pittsburgh (USA) stem cell project. The context is injecting stem cells from young mice into very old mice and mice with progeria, a disease that causes rapid aging. As described in Nature Communications [03 January 2012, Open at publication, Muscle-derived stem/progenitor cell dysfunction limits healthspan and lifespan in a murine progeria model] the experiments showed that progeria mice, which normally survive only 21-28 days, can live more than 66 days and attain nearly normal size with generally better health. As Dr. Niedernhofer is indicating, this isn’t the fountain of youth, but this is a use of stem cells that can provide insight into the process of aging. More »

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Off to Mars. Yes and no.

It hasn’t escaped notice that the Russians (with a Chinese probe) tried sending a mission to Mars, Fobos-Grunt-Yinghuo, which spluttered into low Earth orbit and presumably will fall back to Earth. Meanwhile, NASA the U.S. space agency lofted another Mars mission, MSL Curiosity, that is happily on its way to the Red Planet.

If this had happened, say, thirty years ago; it would have been an occasion for great nationalistic clucking and crowing. These days, people notice the irony, perhaps. More likely, with the tightening of budgets for space everywhere, the loss of any major expedition is viewed with dismay.

Mars is a difficult target. More than one-half of the missions have failed, some like the recent Russian Fobos-Grunt project fail even before leaving Earth orbit. Others, such as the NASA Mars Polar Lander crashed into the Martian surface. It’s known as the Mars Curse, but in truth it’s the complexity of the journey and the various requirements of landing on a major planet that demand near perfection in every detail, which is difficult to achieve.

Mars is often cited as the most important destination for human space exploration. Conceptually, this is certainly so; Mars has more to offer humanity – including possible colonization – than any other planet or moon. However, Mars Curse or not, it’s clear that Mars is logistically very difficult – beyond our means (money and technology) at least for the time being. What I just wrote can be vociferously disputed, but I wouldn’t take any bets on a manned Mars mission happening within two decades.

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Zircons provide new reading on the atmosphere for origin of life

How can you tell what the atmosphere of Earth was like four billion years ago? The answer is simple, although technically difficult to do – read the rocks. Geologists and now astrogeologists and astrobiologists go back to the question of what the atmosphere was like during the early history of Earth because it is one of the key ingredients in the explanation for how life formed. To get their answers they have become very clever at reading the rocks, or in this case the zircon.

Zircon is a very common trace mineral in many kinds of rocks and soils. It’s relatively hard, crystalline material that, among other things, often contains trace amounts of radioactive elements uranium or thorium. The radioactivity has made it possible to date zircon with considerable precision, leading to the discovery that some zircons were formed about 4.4 billion years ago, the oldest known minerals.

Scientists at the New York Center for Astrobiology at Renssalaer Polytechnic Institute reasoned that zircon might also be used to determine what kind of gasses were present in the magma that formed the zircons. That, in turn, could reveal what gasses were escaping from magma that reached the Earth’s surface and were contributing to the formation of the atmosphere. Their results, published in Nature [30 November 2011, paywalled, The oxidation state of Hadean magmas and implications for early Earth’s atmosphere] may overturn fundamental assumptions about Earth’s early atmosphere. More »

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New water for life: Lakes on Jupiter’s moon Europa

Europa Lakes
Europa lake formation between surface and ocean….Credit: Britney Schmidt, U.of Texas, Austin

This story begins with chaotic terrain on a moon of Jupiter, Europa. Ever since the space probe Galileo zipped by this part of the solar system and recorded the most detailed pictures of the surface of Europa, astroscientists have pretty much come to an agreement that Europa has a lot of water underneath the icy surface; oceans of water. The question they argued about was how thick was the surface ice? Some said, “Very thick, as in tens of kilometers”; other said, “at times and at certain places, not very thick at all – three kilometers or maybe even water on the surface.” Typically, the thick-icers had believable mathematical models to back up their story. All except for the “chaotic terrain” an area on the surface of Europa that looks exactly like it has icebergs that once floated on water. The thin-icers claimed this patch. Now we can add a third point of view, call them the middle-lakers. More »

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Stem Cells: An excellent coverage of the medical reality

I’ve posted before about the most unusually frank, thorough and intelligent postings on current health issues by the British National Health Service (NHS) called NHS choices, [SciTechStory: Behind the headlines, a systematic source of science candor]. This time I’m drawing attention to a longer piece made available through the site, called Hope and hype: stem cells in the media, which is as the title suggests a rather more sober look at the promise and delivery of stem cells for medical procedures. It’s a real-world topic in that many people are now routinely traveling to countries such as China and Thailand for stem cell treatments that are proscribed or unavailable in western countries – especially those such as the United States, which have developed a legal phobia around stem cell research. This is an issue rife with hype and misunderstanding, which this 21 page, well written and well illustrated paper (pdf) does much to clarify. It’s not against stem cell medicine, not at all, but at the same time it tries to make clear where the science really stands.

The cover page for downloading is at: NHS choices, Hope and hype: stem cells in the media.

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Synthetic biology: Pituitary glands from stem cells

Research into the uses stem cells is at that stage where almost every month a new application is announced, typically in the replacement of damaged cells or tissues. The most recent application is the creation of pituitary gland tissue from the embryonic stem cells of mice. Researchers at the Japanese RIKEN Center for Developmental Biology under Yoshiki Sasai and published in Nature [09 November 2011, paywalled, Self-formation of functional adenohypophysis in three-dimensional culture] have succeeded in not only creating pituitary gland tissue but also in transplanting the tissue successfully into mice with damaged pituitary glands. The results show that they mice recovered all or most of their pituitary output.
More »

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Asteroid 2005 YU55: No impact on the neighborhood

Asteriod YU55
Asteroid 2005 YU55 photographed in passing…Credit: NASA

November 9, 2011: It was a reminder for the neighborhood (Earth and Moon) that strangers pass in the night. Night being metaphorical in this case because the asteroid 2005 YU55 actually took about three days to orbit through the vicinity of the Earth and Moon. As asteroids go, YU55 is fairly large, about 400 meters (1300 ft) wide, what Americans would call a city block. If it collided with Earth it would make a helluva bang, on the order of many megatons of TNT, roughly a nuclear bomb that would make a crater 6.4 km (4 miles) across and 518 meters (1700 ft) deep. Of course, it didn’t this time and probably won’t collide with the Earth in the future; so it serves as a reminder that such asteroids are around and collisions can happen. In fact, because 2005 YU55 also passes close to Venus and Mars during its long orbit, it is subject to gravitational and other forces that can alter its path. Current calculations indicate that despite changes caused by Mars or Venus, the asteroid still will not be anywhere near collision course with Earth when it comes back around 2041, however, there is a margin of error. More »

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Mars 500: The simulation ends

Mars 500 mission
The Mars 500 facility, in a parking lot….Credit: ESA, Wikimedia Commons

It was, as so many jokingly put it, a real down-to-earth mission to Mars. As in, the mission never left Earth. Beginning June 3, 2010 and ending November 4, 2011, the Mars 500 mission took place in a facility at the Russian Academy of Science Institute of Biomedical Problems near Moscow, as a joint project of the European and Russian space agencies. Joking is easy but try looking at it this way: How would you like to step into a windowless room about as big as a studio apartment (12×66 ft or 3.6×20 m) and spend the next 520 days (18 months) with five other people, in this case all men, who until this experiment you’ve never met in your life?

Actually I’m not sure why this story was often treated by the media as something of a joke. Other than the obvious and unavoidable fiction of space travel while remaining on the ground, this was a serious experiment that cost over $15 million. The specially constructed facility, which included a simulated Mars Lander and an ‘external area’ that simulated the surface of Mars, was designed to maintain the isolation and confinement that would actually occur on a 500 day mission. The program included over 100 experiments, some requiring the use of spacesuits and there were many simulated ‘events’ that would typically be encountered by a real space flight. The six cosmonauts maintained communications with Earth, including with their families, but a transmission lag of up to 25 minutes was created, just as it would be on the 54 million kilometer flight. More »

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One voice: Paul Krugman, fracking and solar energy

At best, when an individual such as Paul Krugman (International Trade Economist, Nobel Prize winner in economics and columnist for the New York Times) opine in a public forum, it’s an insightful piece of analysis, a useful expression of sentiment, or an effective way of providing sorely needed background on important issues. Occasionally, however, important things gain momentum because the times were right and a single voice forcefully articulates what is happening. This may be one of those occasions: Paul Krugman has published his belief that solar energy’s time has come. More »

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The seven billionth baby

At a relatively arbitrary date, October 31, 2011 at a relatively arbitrary time of 11:58 PM in Manila in the Phillipines (near the International Dateline), a relatively arbitrary baby (Danica May Camacho) was born – the seven billionth person alive on Earth. That is according to the United Nations Population Fund. The U.S. Census Bureau begs to disagree, saying that seven billion won’t be reached until March, 2012. There are many other estimates.

Obviously human beings can’t agree on anything important. I’m sure there are those who deny there are seven billion people on Earth for no particular reason other than its easy to deny something and force others to prove them wrong – which in this case they can’t, because they can’t agree on the answer.

Meanwhile the population of the Earth continues to grow, on its way toward a probable ten billion or so by the end of the century. Is that too many people? There’s no agreement on that either. Mind you, I’m not complaining about the lack of agreement. If we can’t agree on trivial things, I don’t expect agreement on really big things. In fact, the bigger it is, the less likely we are to agree.

Not that it’s necessary or even desirable to agree about everthing; although it would be beneficial if we could agree about things involving the fate of the Earth like global warming, overpopulation and nuclear holocaust. Don’t you agree?

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DNA computing: Genetic expression used for computer logic

Over the last few years it’s been shown theoretically and with some prototype devices that a biological computer is possible. That is, a digital computer where the components are built not of silicon or metal but with organic material. The question has become not can a biological computer be developed, but how – or more to the point, how best? Therein lie the ongoing lines of research. It’s tempting to call it a competition, although all approaches at this point are so new that it’s difficult to even compare them, much less evaluate them.

One of those approaches, in development by a team at the Imperial College of London (England) led by Baojan Wang and Richard Kitney, uses DNA cultivated from the common stomach bacteria Escherichia coli (E. coli). As published in Nature Communications [13 October 2011, paywalled,Engineering modular and orthogonal genetic logic gates for robust digital-like synthetic biology], their approach uses gene expression – the ability of a gene to produce proteins – as the core mechanism for a logic gate. Logic gates with names like AND, OR, NOT, NAND are key pieces of digital computers that perform many of the processing functions. Building these gates from DNA uses the combinatorial capability of genes in much the same way as “on” or “off” works for electronic circuits. More »

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The mystery of dark matter in small galaxies

Considering that dark matter is supposed to make up about 23% of all mass-energy density in the universe, it’s surprisingly difficult to pin down. It can’t be seen or measured directly, that much is known. Its existence is inferred from gravitational effects on things that instruments can see and from gravitational lensing (the bending of light as it passes through galaxies).

One of the prevailing inferences, generated by computer models, is that dark matter should clump together toward the center of galaxies. This clumping allows the material in dark matter to condense into visible matter, eventually forming stars and galaxies that we see with our eyes and telescopes. This behavior is obviously fundamental to the notion of how the universe forms, its cosmology.

A good place to look for the effects of dark matter is in so called small galaxies. These are galaxies with only a few million stars; a normal galaxy has hundreds of billions of stars. With so few stars, it is estimated that small galaxies are about 99 percent dark matter, which should increase the probability of detecting the effects of dark matter. A new study of small galaxies by Matthew G. Walker and Jorge Peñarrubia at the Harvard-Smithsonian Center for Astrophysics (Cambridge, Massachusetts, USA) to be published in The Astrophysical Journal and available online [arXiv [11 August 2011 A Method for Measuring (Slopes of) the Mass Profiles of Dwarf Spheroidal Galaxies] looked at the distribution of matter in two ‘neighboring’ small galaxies of the Milky Way, Fornax and Sculptor. More »

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The Global Warming controversy is ended…

climate graph
Global surface temperatures………Credit: Berkeley Earth Project

The Global Warming controversy is ended. Right.

Take a look at the graph above. It shows the results of global temperature measurements over a span of some 100-200 years as compiled by four groups: NASA Goddard Institute for Space Studies, NOAA (National Oceanic and Atmospheric Administration), United Kingdom Meteorology Office Climatic Research Unit (hadCRU), and the Berkeley Earth Surface Temperature Project. Notice that the graph lines are almost identical and they all show a strong trend in global warming.

This is not exactly news, is it? No, but one line in the graph of particular interest is from a report that is making its way toward official release. It’s important because the data for that line on the graph is from those skeptical of scientific measurement of global warming. The Berkeley Earth Surface Temperature Project was begun by University of California physics professor Richard Muller, a man highly critical of the manner in which climate scientists were gathering and manipulating their data. Initial project funding included sources that generally contribute to climate change denial. Muller’ stated goal was to establish an independent source of climate data that would be thoroughly vetted for bias and error.

The Berkeley team, ten scientists led by Robert Rohde, a specialist in climatology with large data sets, included Saul Perlmutter, this year’s Nobelist in physics. The goal was to assemble a merged set of climate data from surface weather stations, check it for various errors, bias, or other distortions, analyze it with new and existing statistical methods, and provide public access to all the data and results. The result of the multi-year project is a database of 1.6 billion records of climate data, and a report that is now available at the website [Berkeley Earth Surface Temperature], which is heading for peer review and publication. Though not final, this is the official report. More »

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Dennis Ritchie 1941-2011

Not many people outside of the computer industry know of Dennis Ritchie. Most programmers know who he was because whatever their programming language of choice, they know about the continuing influence of the “C” programming language and the Unix operating system. Dennis Ritchie was the primary developer of both. Together “C” and Unix underlie much of the software of the world – yes, including Apple software and the Linux operating system. “My undergraduate experience convinced me that I was not smart enough to be a physicist, and that computers were quite neat.” He was a modest man who contributed a great deal to the way the modern digital world works.

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Epigenetics in the brain: Evidence of methylation beyond cell division

Methylation is not a gasoline additive process or nor does it have anything to do with amphetamines. I mention this because methylation is proving to be significant. It is something that happens to your DNA and despite not being very well known by the public, research is showing it to be far more important than was suspected even a few years ago. I want to mention an example of that research from neuroscience that sheds some light on that importance. More »

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Steve Jobs, entrepreneur, artist

Forest Gump, the paragon of grace under incomprehension, remarked about making a great deal of money “from a fruit company.” He had no idea, but the audience did. Everyone saw the image of the colorfully striped apple and knew what it meant. Steve Jobs and his company, Apple Computer, touched almost everybody.

Jobs and company brought forth some wonderful technology, which we honored by buying in the millions. For my money though, it wasn’t just the technology – it was the aesthetic. Apple products were insistently an amalgam of function and style, which I think it’s fair to say sometimes reached the level of art. This is Steve Jobs stamp on the future; he insisted upon style and demanded that his customers pay well for it. Only the best commercial artists are successful in doing that.

With Steve Jobs it was often my way or the highway, but a clever guide can often find the way along a road not yet taken. He was good at that, though at times deceived by his own vision, he was always looking, trying, finding the next ‘insanely great’ product.

I hope we remember his insistence on high standards for a long time.

Steven Paul Jobs – February 24, 1955 – October 5, 2011

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The Nobel Show

There is nothing else like it in science, the annual awarding of the Nobel Prizes for physiology or medicine, physics, chemistry and economics. I wish the awards were as eagerly anticipated by the world’s populations as say the Super Bowl or the World Cup; but this is the biggest show in science. I also wish the prizes were more comprehensive, but that’s an old complaint.

Perhaps you’ve heard people say about the work of a scientist, “That’s Nobel worthy.” What they mean is that there is a relatively discernable level of work that is more likely to garner a Nobel prize. A question might be, “So why aren’t all scientists doing something Nobel worthy?” It’s actually a good question, because it goes to the heart of the motivation for doing science.

Science is done for a lot of reasons, a paycheck is one. To answer a difficult question is another. To discover something totally unknown is yet another. Just doing enough to get a paycheck may be a noble effort but doesn’t warrant a Nobel. Answering a difficult question might get a Nobel, if it’s something really important, but working on a well-known question is not particularly risky. Nobel committees prefer to reward scientists who stick their necks out to discover something new or better yet, surprising.

Nobel prizes are most often awarded to scientists who are or were working at the cutting edge of their field (or even beyond), yet manage to produce results that survive criticism, and that can be verified, reproduced and go on to contribute to the advancement of scientific knowledge. This is truly difficult to do.

I like to ask people, “A century or two from now, who do you think will be remembered most – athletes, politicians, generals, CEO’s, or Nobel pize winners?”

UPDATE 4:
The Nobel Prize in Economic Sciences goes to Christopher Sims and Thomas Sargent for their empirical research on cause and effect in the macroeconomy. Translated: Sims and Sargent are noted for their work in ‘rational expectations’ (RATEX) in economic behavior, a highly controversial approach that however has spawned a large number of practical techniques that are in routine use in business and economics.

UPDATE 3:
The Nobel Prize for Chemistry goes to Daniel Shechtman for the discovery of quasicrystals. The controversial discovery was a perfect example of a scientist sticking his neck out with extraordinary, surprising and almost unanticipated results. It took decades of continued work before quasicrystals gained mainstream acceptance – now, the Nobel Prize.

UPDATE 2:
The Nobel Prize for Physics goes to Saul Perlmutter, Brian P. Schmidt and Adam G. Reiss for the discovery of the accelerating expansion of the Universe through observations of distant supernovae. I’d add, for their even more important – or provocative – positing of dark matter (or dark energy) to explain the expansion.

UPDATE 1:
The Nobel Prize for Physiology or Medicine goes to Bruce Beutler and Jules Hoffmann for their discoveries concerning the activation of innate immunity and to Ralph Steinman for his discovery of the dendritic cell and its role in adaptive immunity. Dr. Steinman was awarded the prize post-morten, a first for the Nobel Prize, as he died between the time the Nobel committee made its selection and the time of the announcement.

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DNA nanosensors

Not all sensors are electronic, or at least if you expand the scope of sensor technology, measurement techniques (which is what sensor technology is about) can also be chemical or physical, among other things. In this case, the sensor is built from DNA and it’s called a DNA nanosensor.

The idea behind this particular nanosensor came from study of natural biosensors within cells. All living things monitor their condition, from the largest scale of organs to the smallest nanoscale chemistry of individual cells. At the level of the cell, there are billions of specialized proteins or RNA that perform the task of a sensor by reacting to the presence of very specific molecules. For example there are many loops or cyclical chemical pathways, where a certain condition, say a need for energy, triggers a chemical and physical change in one sensor protein. It in turn signals for production of more energy. When enough energy is produced, another sensor protein accumulates to the point where it turns off energy production.

Scientists at the University of California, Santa Barbara (USA) and the University of Rome Tor Vergata wanted to emulate this natural sensor-signal process with a specific target in mind. As published in the Journal of the American Chemical Society [04 August 2011, paywalled, Transcription Factor Beacons for the Quantitative Detection of DNA Binding Activity] they developed a sensor made from DNA that becomes luminescent (glows) when it encounters a particular protein of the type called a transcription factor. These are proteins used by cells to control the production of molecules (usually other proteins). There are literally thousands of transcription factors, but when scientists ‘reprogram’ cells for example in stem cells; they often change only a handful of factors. The trick is to know whether the reprogramming has worked properly or not. That’s where the nanosensors come in. More »

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The Prestige: China orbits practice unit

The Heavenly Palace is in orbit, or at least the first practice piece – Tiangong 1 – is in orbit. CNSA, the Chinese National Space Agency reports that the 10.5 meter cylinder is designed to practice docking and other aspects of orbital navigation over the next 3-5 years, with the ultimate goal being a functioning space station by 2020.

Most western media have commented on the political (PR) aspects of this event. All such space efforts are political, in China or elsewhere. This project is interesting because of the contrast to the International Space Station (ISS), the decades-long effort by a consortium of countries. In this case China is following a resolutely go-it-alone approach. Although the program relies heavily on Russian space technology, there is nothing collaborative about it.

What’s more interesting is that the Chinese space effort is not being used in an organized way to flagellate the public into support for NASA or other western space agencies. There’s no Sputnik effect. Why?

One possibility is that experience with the ISS has taught NASA and others that until the problem of costly and dangerous transport between station and Earth surface is more than marginally improved, large permanent space facilities are not worth it. The amount and quality of research produced by the ISS is nowhere near what was expected. The Russians, in their blunt fashion, suggested that the ISS consortium let the $100 billion station fall into the ocean in 2020. So if the Chinese wish to build their own albatross for prestige purposes…let them have at it.

There is also speculation that the Chinese have military purposes in mind. However, space platforms such as the ISS are too public, too complicated and inconveniently multipurpose to be very appealing for the military. I wouldn’t rule it out, but it’s more likely the Chinese military will use specialized and highly secret satellites, just like the military elsewhere.

It’s most likely that the Chinese have chosen their space program to mark their national ascendency in science, technology and wealth. The U.S. and Soviet Union did that for a while, but the Russian economy collapsed and the Americans lost focus. Now we get to watch what the Chinese can do when faced with the same problems.

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Kindle Fire ices the future of pads

Many moons ago Apple brought forth the iPad and it was well received. This was a minor miracle as all the pad or tablet computers that had gone before it were great disappointments, each failing to bring excitement or even utility to the tablet format. The iPad, as usual the slightly eccentric somewhat overpriced Apple product, managed to be something people wanted and lo, the tablet computer format was legitimized.

What Jobs wrought has Bezos now solidified. The Amazon Kindle Fire is a smaller tablet computer (7 inch screen compared to 9.7 inches), but plays well with what it is intended to run: Media, media, media. The Fire is nifty, relatively cheap ($199) and will drink from the deep well of content (books, movies, music) stored within the Amazon.com cloud. Fire is therefore a worthy competitor, ultimately for the content in Apple iCloud and also of some Apple products, mainly the iPod Touch, if not precisely the iPad. In the name of competition, all hail the Fire!

After the cheering dwindles, return to your senses and pay close attention to the strengths and weaknesses of the Fire that time will reveal. We know already that it is not a substitute for a true e-book reader. Standard Amazon Kindles will, for a while at least, prevail in that market. What else will it do less than well? Or if you prefer, what will it do best?

In the long run (say about 9 months in the consumer computer business), things will be different, but for now we have not only a competition, but tablet computers are now almost certainly destined to a prominent future.

nk

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Have some neutrinos broken the law?

You know the old joke, “The speed of light: it’s not only the limit, it’s the law.” I used to think the joke was really lame, because if the speed of light were like a human law, then it could be changed. But the speed of light is a universal constant, invariant, and one of the foundations of modern physics. Perhaps you also heard, unless the din of other distractions prevailed, that scientists at the Gran Sasso Laboratory in Italy announced the measurement of a group of neutrinos moving faster than light.

Specifically: Neutrinos produced by the Super Proton Synchrotron at CERN in Geneva Switzerland were directed toward the Gran Sasso facility deep within the mountain of the same name, a distance of some 730km (455 mi). All other nuclear particles won’t go that far, but among the many weird particles in physics, neutrinos take the prize. In this case, the relevant fact is that neutrinos pass through matter – rock, metal, water – like matter doesn’t exist. So, 0.0024 seconds after the neutrinos are produced in Switzerland, they show up passing through bricks of photographic film in Italy. The interesting part, gathered from the OPERA experiment, is that at least some of the neutrinos show up 60 nanoseconds faster than if they were travelling at the speed of light. That’s 0.00000006 of a second faster. The results are published at arXiv [22 September 2011, Measurement of the neutrino velocity with the OPERA detector in the CNGS beam].

If the experimental results are correct, this is…like…awesome. I’m being deliberately obtuse. I know the number is very small; but that is absolutely and relatively not the point. If the speed of light can indeed be broken, a whole lot of physics needs to be re-thought and Einstein probably needs to be reburied. At the moment the implications of the discovery seem to be driving much of the coverage, but it’s way too early for anything other than thought experiments. Real science needs to do its thing. Discoveries of this magnitude must be verified, repeated, challenged and confirmed or not confirmed. The scientists involved are, obviously, no dummies. They are well aware of the burden of proof. They did what they could to check, re-check, examine and criticize their methods and results. Now they have released the information, which they consider preliminary, to the rest of the scientific community. Have at it! Which indeed they will because as Carl Sagan was fond of saying: Extraordinary claims require extraordinary evidence. Besides, nothing gets scientists engaged so much as something that threatens to destroy their work.

If you polled 100 physicists this morning, probably 98 of them would say something like, “What interesting results! No doubt wrong, of course.” The probabilities are that’s correct. Equipment calibration, measurement error, unidentified forces – there are many ways an experiment of such delicacy and precision can go wrong. However, the original scientists did their homework; they established a six-sigma level of confidence in their results. Five sigma would normally suffice to get attention.

However, don’t hold your breath waiting for a resolution. It will take years to play out. New experiments to recreate the measurements will need to be put in place; that alone could take months to years. Undoubtedly there will be some new theoretical modeling. There will be controversy. So be patient; there should be a number of interesting moments yet to come.

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Sci-Fi Movie Review: Inception

[Inception. Directed by Christopher Nolan. Released July 16, 2010. DVD/Blu-Ray released. As usual, the review contains many spoilers.]

I’m going to try something unusually, um, structural for this review. It’s in keeping with a structural notion of dream levels used in Inception and it may help shed some light on the divide that separates the idolaters from the unimpressed. By the divide I mean the many fans of Inception who are convinced that it is one of the greatest movies of all time (8.9 IMDb rating and top 250 movie), versus those who, in various words to the effect, think it is crap. There seem to be very few in the middle. Maybe that’s the interesting point. More »

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Adenosine: A blood-brain barrier beachhead

Introducing medicine into the bloodstream is generally a very efficient method of distribution, except for the brain. When it comes to the physiology of the vascular system (arteries, veins, capillaries), the brain is different. In the brain, especially for the millions of capillaries, the cells that build their walls form what is technically called the hematoencephalic barrier, better and more easily known as the blood-brain barrier. The blood-brain barrier prevents most bacteria and many toxins (poisons) from entering the cells of the brain through the bloodstream. Meanwhile it permits the relatively free exchange of things needed for metabolism such as oxygen, carbon dioxide, sugars and certain proteins such as hormones. Much to the frustration of medical research, the blood-brain barrier also blocks most forms of medication.

Scientists have been trying to find ways of crossing the blood-brain barrier for at least a century – without a great deal of success. The barrier is ‘porous,’ as it must be to do the job of carrying life-sustaining substances to and from the cells of the brain; but it is very selective about the size and type of molecules it permits to cross the barrier. This selection takes place in the membrane of the blood vessels, where the chemical and physical configuration of proteins blocks or permits passage of molecules. In general there are three main approaches to getting medicine across this barrier: Piggybacking on molecules known to be able to cross the barrier, using nanoparticles small enough to ‘slip through’ the barrier and using chemical stimulators to alter the protein configuration in the barrier (something like opening a gateway). The latest effort, which counts as a success, by a research team at Cornell University (Ithaca, New York, USA) and published in the Journal of Neuroscience [14 September 2011, paywalled, Adenosine Receptor Signaling Modulates Permeability of the Blood–Brain Barrier] uses the last approach. More »

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HARPS finds a batch of 50+ new exoplanets

Punch up the numbers, add more than fifty planets to the count of those that potentially could harbor life, bringing the total almost to 700. These new exoplanets were discovered by the HARPS (High Accuracy Radial Velocity Planet Searcher) at the La Silla Observatory in Chile. The announcement, at the Extreme Solar System conference in Grand Teton National Park, Wyoming (USA), includes 16 so-called ‘super-earth’ planets – those that are Earth-like in rocky composition but are larger in size. This is the largest batch of exoplanets yet discovered.

HARPS is the most successful planet hunting device to-date, with more than 150 credited to its analysis. It searches among 376 Sun-like stars, those relatively near to our own Sun, to detect as many low-mass (that is, smaller) planets as possible with the radial velocity technique. This approach uses the Doppler effect, which displaces a star’s spectral lines (color spread), to detect the presence of planets in orbit around a sun. At the moment, with relatively limited sensitivity, HARPS can only detect fairly large planets – roughly the size of Neptune in our own Solar System. Even with that limitation, HARPS has so far revealed that at least 40% of the suns it has observed have at least one Saturn-size planet. If this number holds up, it will mean yet another expansion of the estimate for planets – billions in just this galaxy alone. What is the probability that some of these planets have life? More »

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Tuning for terahertz waves with graphene

As you may already know if you follow science and technology even a little, graphene is a wonder substance. It’s a cousin of graphite, the stuff in ‘lead’ pencils, which is to say pure carbon. It’s growing array of properties are generally a result of two things: Graphene is a layer of carbon only one atom thick, which makes it, in fact, two dimensional and the carbon is organized into hexagonal format (honeycomb). The extreme thinness combined with the specific format of the atoms has produced all kinds of unexpected results in experiments. This is especially true of what graphene does with light and other waves of energy.

As you also probably know, energy in the form of electromagnetic radiation has wave-like behavior that is classified by the frequency of the wave and its wavelength. This is the electromagnetic spectrum from radio waves, which are very large (some are millions of meters), to gamma rays, which are measured in trillionths of a meter. Visible light, the portion of the electromagnetic spectrum our eyes use, is one of the bands in the spectrum. The bands, roughly twenty of them, are ranges of wavelength and frequency. Most of them have proven valuable to science and technology. In fact, it’s legitimate to think of the bands like real estate, a limited and therefore valuable resource. The more useful bands, like radio and microwave, are so valuable that a great deal of money is paid to use them. You’ve probably heard of bidding wars over bandwidth. More »

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