SciTechStory Categories

  • News: SciTech news with impact
  • Impact: Explanation and analysis
  • Essay: General SciTech topics
  • Spun: Other sides of SciTech
  • Funnybone: Humor in a SciTech vein
  • Review: Reviews of sci-fi films
  • Commentable: Selected reader comments

Impact Areas

SciTechStory tracks science and technology through the filter of "Impact Areas" - those areas which are likely to have the most impact on (human) life.

Read more about Impact Areas

Getting your head around huge brain projects

As the ‘thinking’ goes – a billion here, a few billions there and eventually we’ll know how the brain works. The billions are Euros and dollars. The “there” are two projects aimed at learning how the human brain works. Even President Obama got into the act a while ago to mention in the State of the Union address about U.S. government funding for the Brain Activity Map project. Though at the moment this project is hardly more than an interesting article in the journal Neuron. The underlying assumption is that neuroscience is ready for big breakthroughs, if only there is enough money to coordinate and fund a massive research project – sort of like the all-out effort of putting man on the moon. Only in this case, substitute “explaining mental activity” for the “getting to the moon.”

If that sounds like an odd juxtaposition, it should. The Moon is a very real, measureable, and as we’ve seen, reachable object. Mental activity – with such useful but nebulous concepts like ‘thinking,’ ‘intelligence,’ ‘rationality,’ ‘memory,’ ‘cognition,’ or even (shudder) the soul – is elusive, controversial and vastly complex.

There is a similarity in the brain projects to the Human Genome Project of the 1990s. At the time the human genome project began, it seemed like mapping all of the genes in human DNA would provide a road map to cure thousands of diseases, unlock the secrets of human development and generally bring about a new level of understanding of the ‘blueprint’ of life. At the time, biochemists were just beginning to understand the chemical pathways by which DNA is created and goes about its work. As it turns out, this research led to the discovery of an entire field of study – epigenetics – that seeks to explain how genes are expressed and regulated. The knowledge of epigenetics vastly complicates the interpretation of DNA. For example, where medical researchers once thought that reading the human genome would lead to explaining and curing thousands of diseases, they now believe that perhaps 1 to 3 percent of diseases have a purely genetic cause. Otherwise, most diseases including cancer, heart and neurological disease are a complicated mixture of genetic, epigenetic and environmental causes. In short, the Human Genome Project was important, influential and worth the effort – but it was hardly the answer to all the mysteries of DNA or of human development. More »

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Planck’s Universe

Planck map of the CMB Universe
Cosmic Microwave Background radiation map of the Universe…Credit: ESA, Planck Collaboration

The big news for this week and I do mean big as in as big as the whole Universe, is a new collation and analysis of data from the European Space Agency’s (ESA) Planck observatory mission. The new analysis reveals several things about the observable Universe that revise astronomer’s thinking.

The Planck observatory is a satellite, the flagship mission of ESA launched with the assistance of the U.S. space agency NASA, that sits in a location over a million kilometers from Earth. It scans the observable Universe for tiny differences in the Cosmic Microwave Background (CMB), the faint traces of radiation (photons, light particles) that are remnants from the Big Bang. The Planck microwave receivers are the most sensitive and technically sophisticated yet assembled and they have made it possible to map the fluctuations (“hot or cold”) in the Universe to an unprecedented degree of resolution. It is providing astronomers with a picture of the Universe only 380,000 years after its formation in the Big Bang (which in cosmic time is only trillionths of a second). From this information, a great deal can be deduced about the nature of the Universe: More »

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Micro-endoscope: A visual probe as thin as hair

Micro-endoscope diagram
A schematic of the micro-endoscope….Credit: Joseph Kahn, Stanford University

The endoscope, a thinish, flexible tube with a light and image sensor or lenses at the probe end, is an indispensable tool of medicine, especially surgery. Endoscopy, the technique of using the endoscope, is the driving force behind minimally invasive surgery, which is radically changing the way modern surgery is progressing. The minimally invasive approach seeks to reduce the amount of tissue damage caused by the surgical procedure. In older, traditional methods large incisions are cut through the flesh to access underlying organs. In many cases, the amount of cutting for access far exceeds the cutting at the actual target of the surgery. With minimally invasive surgery, only three to five ‘ports’ are cut through to the target, one specifically for the endoscope.

Since the cut must be big enough to accommodate the diameter of the endoscope, the smaller the endoscope, the smaller the incision. This obvious correlation led to a research effort to decrease the size and complexity of the endoscope. The best result to-date, published in the journal Optics Express [24 February 2013, paywalled, Resolution limits for imaging through multi-mode fiber] and developed by a team of engineers at Stanford University (Berkeley, California USA) uses a single fiber-optic strand to achieve resolution of 2.5 microns in size, with 0.3 microns resolution a goal for the near future. The human eye is able to resolve about as small as 125 microns, that’s in thousands of an inch – a tiny grain of sand or a thin hair. The best current endoscope can resolve about 10 microns, so the new “micro-endoscope” represents a major step in terms of both endoscope size and resolution. More »

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Big Telescopes: ALMA already on the job

ALMA Telescope
Some of the ALMA antenna array at Atacama….Credit: ESO

Today, March 13, 2013 marks the official ‘opening’ of the world’s largest telescope, ALMA (Atacama Large Millimeter-submillimeter Array). As the biggest and most complex telescope project in history, astronomers hope it will open a new chapter in the observations of the cosmos. Located near San Pedro de Atacama in Chile, it is the crowning achievement of those who believed that with modern technology a ground-based telescope array can perform as well as those in space. It’s also a lot easier to visit.

ALMA underwent ten years of construction, 1.4 billion dollars in cost and pushed the world’s radio astronomy technology to the max. A total of 19 countries have contributed to ALMA, through three primary partners: the European Southern Observatory (ESO); the National Astronomical Observatory of Japan; and the US National Radio Astronomy Observatory (NRAO) in Charlottesville, Virginia, funded by the US National Science Foundation (NSF). The United States alone contributed about $500 million to the project, the largest such outlay for any such facility in the world.

Consisting of 66 antennas, the last to be installed later this year, the array is brimming with the latest breakthroughs in radio and infrared receiver technology, much of which concentrates on focusing and refining the faintest signals in the universe.

The inaugural week includes the usual hoopla and ALMA is reporting results. In other words, this week is ceremonial, as the array has been in operation with a reduced number of antennas since 2011. The website: http://www.almaobservatory.org/ is well stocked with information and the first reports of ALMA observations.

A good overview of the project, warts and all, is available (free) at the journal Nature [14 March 2013, Radio astronomy: The patchwork array]

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“Gray Mars” and the stuff of life

Bore hole in Mars rock
Rover Curiosity’s bore hole in Mars rock, note color change from reddish to gray

Scientific knowledge requires a process of confirmation, for example, scientists have believed for decades that Mars had water and may still have it either in ice form or in the underground. This belief started with observations drawn from Mars photographs from the earlier orbital missions in the 1960’s. Several decades later, the amount of confirmatory evidence is overwhelming. There’s no doubt Mars had water, probably lots of it and an entirely different climate. There’s still water on Mars, we know of the ice form; there remains a possibility of underground water.

Based on our Earth experience, where there’s water (liquid form), there’s life. Consequently, scientists have long speculated that at one time, or possibly even now, life existed on Mars. The evidence for that is not yet conclusive, one way or another; but pieces of the story continue to accumulate. The latest, and in many ways the most promising (short of actually finding something alive or remnants of something that was alive) are reports from a sample drilling made by Curiosity, the latest U.S. Mars rover. More »

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Epigenetics ‘leaks’ into trans-generational inheritance

One of the bigger and most important ‘debates’ in biology – both now and in the past – is whether adaptations made for the environment of a single individual can be inherited by its offspring. This is not about genetic inheritance, mutation, and the reproduction of the genes in DNA. This is about epigenetics, the way in which the genes are regulated. It is an article of central biological dogma that all trans-generational inheritance (parent to children) is the result of DNA and genetic action. While over the last decade or two, it is apparent that epigenetics is abundantly active within dividing cells (mitosis); it is supposed to be non-existent for procreative cells (sex cell meiosis). Evidence for this comes from a number of studies demonstrating how primordial germ cells, cells that are the precursors to the egg and sperm, are routinely and efficiently stripped of their epigenetic markers.

Now comes a study from the University of Cambridge (UK) and reported in the journal Science [25 January 2013, paywalled, Germline DNA Demethylation Dynamics and Imprint Erasure Through 5-Hydroxymethylcytosine] showing that while most epigenetic markers are indeed efficiently and systematically removed – the process is imperfect; some of the epigenetic markers are transmitted to the next generation. One way of putting it, epigenetic markers leak into genetic trans-generational inheritance. More »

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Glia brain cells: Not just infrastructure

So many stories about this recent neuroscience research begin with – “human brain cells make mice smarter” – and miss the point of the research almost entirely. It’s not about mice. It’s about a type of human brain cells, glia, which are just now coming into focus for neuroscience. For those that understand the prolog, this research is, ahem, revolutionary.

To be fair, the paper itself, by Goldman and Nedergaard and published in Cell, Stem Cell [07 March 2013, Forebrain Engraftment by Human Glial Progenitor Cells Enhances Synaptic Plasticity and Learning in Adult Mice] sounds like it’s about mice. Of course, mice are involved, but what the research did – put human glial (white matter brain cells) into mice brains – sheds far more light on what glial cells do in humans than on the fact that the mice became a tad bit smarter. The research demonstrated that glial cells most likely have a significant role in human intelligence.

Why this should be considered important, even revolutionary, goes back to the “Neuron Doctrine” developed by Ramon y Cajal more than a century ago, which states that all information processing and communications in the nervous system takes place between neurons. Since glia do not have any of the hallmarks of neurons (dendrites, synapses, axons), they were considered unimportant to information processing and cognition. The general attitude, which is still probably the majority opinion today, was “there are neurons,” where all the mental action begins and ends, and then there’s “the white stuff,” the glial cells that sort of hold the brain together and do housekeeping – basically infrastructure material.

More »

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CRE: A killer coming to a critical care facility near you

It is not pandemic, not yet, but the spread of a particular form of drug resistant bacteria is serious enough to warrant this March 6 statement from Dr. Thomas Frieden the head of the United States Centers for Disease Control and Prevention (CDC):

CRE poses a triple threat. First, they’re resistant to all or nearly all antibiotics. Even some of our last-resort drugs. Second, they have high mortality rates. They kill up to half of the people who get serious infections with them. And third, they can spread resistance to other bacteria. So one form of bacteria, for example, carbapenem-resistant Klebsiella, can spread the genes that destroy our last antibiotics to other bacteria, such as E. coli, and make E. coli resistant to those antibiotics also… We only have a limited window of opportunity.

[Source: CDC: Action needed now to halt spread of deadly bacteria]

CRE is the acronym for the tongue twisting carbapenem-resistant Enterobacteriaceae, where carbapenem is one of the major antibiotic groups of last resort and Enterobacteriaceae is a large family of seventy gut-dwelling bacteria (including the ever present forms of Escherichia coli – E. coli, Klebsiella, Salmonella and Shigella). These are bacteria generally present in the human digestive system, often kept at low and relatively harmless levels by natural defenses. However, for people whose immune systems are weakened or in situations where more virulent forms of the bacteria are present – these bacteria can become killers. More »

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ePSC: A new type of pluripotent stem cell

Researchers at the University of California San Francisco have discovered a new type of stem cell. This does not happen every day, guaranteed. In fact, this discovery is potentially very important. Called an endogenous pluripotent stem cell (ePSC), it has much the same characteristics as embryonic stem cells, the ability to become almost any other kind of cell. However, the ePSC was found in human breast tissue. It’s relatively rare, but still a viable source of pluripotent stem cells that ought to avoid the controversies associated with anything embryonic. More »

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Mapping commercial sea routes in the Arctic Sea

Arctic Sea Routes
Map of potential Arctic Sea shipping routes…..Credit: UCLA

Last year (2012) 46 ships made the journey over what used to be considered the mythical “Northwest Passage” – they sailed through the Arctic Sea from Hudson’s Bay to Alaska and beyond. They had to wait until late summer and voyage in the company of icebreakers for safety – nevertheless, think about it: For the first time in recorded history, a continuous sea-voyage from the Atlantic to the Pacific via the Arctic Sea is possible – commercially possible. Why is that?

Global warming.

The map above, drawn by researchers at the University of California Los Angeles and published in the online journal Proceedings of the National Academy of Sciences [25 January 2013, New Trans-Arctic shipping routes navigable by midcentury] outlines the potential commercial sea routes over the Arctic by the period 2040-2059. By that time sea transport in the Artic will be more or less routine and the ships will not need ice breaker escorts. How is this possible?

Global warming.

In fact, the projections are for the polar ice to thin so much that a direct route over the pole with icebreaker support may be possible. This will cut the trip from Europe to Asia by at least 20%. Even though the Arctic routes will probably never be available year-round, the commercial appeal to shippers is obvious. With it will come a great push to open up the routes, establish supply lines, communications support, new towns, new port facilities and there’s the distinct likelihood of shipping oil and gas from wells in that region. As more land area opens from melting snow and permafrost, the exploration for resources grows with it. All because of…

Global warming.

Of course, none of this including the 46 ships and record low ice-pack in the Arctic Sea could possibly be real….

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A first: wireless, broadband, rechargeable, implantable brain sensor

Wireless brain sensor
A little something on the mind…wireless brain sensor Credit: Fred Field, Brown University

It may seem that in this age of wireless everything that sensors for the brain should have been wireless years ago. After all, if test subjects (people or animals) must be tethered to power cords and data cables, then the range of activities and environments will be limited. However, the technical difficulties of constructing a fully wireless, rechargeable sensor brain implant system are formidable. There have been many attempts; the first to fully succeed was reported in early 2013 by a team from Brown University (Providence, Rhode Island USA) in the Journal of Neural Engineering [21 February 2013, paywalled after 30 days, An implantable wireless neural interface for recording cortical circuit dynamics in moving primates ]. More »

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Citigroup: Solar energy profit-ready for large consumer companies


Solar Cell Efficiency

The research paths toward better solar conversion. Credit: NREL (Wikimedia commons)

According to a proprietary investor’s report from the mega-bank, Citigroup (New York USA) large consumer electronic brands are about to enter the solar energy market. This was the news slipping by on the business crawl Thursday February 28, 2013. It wasn’t big news. Known for being relatively bullish on solar energy, Citigroup has programs to put its money on its analysis. Still, this report looking into the glass ball about the future of solar energy is another indication that solar is becoming competitive. Citigroup’s principle analyst on the subject, Shar Pourezza, foresees solar farms as price competitive with the cheapest of fossil fuel energy, natural gas.

“In Germany, Spain, Portugal, Australia and the South-West of the U.S., residential-scale solar has already reached grid-parity with average residential electricity prices. In other countries, grid parity is not far away. … We are likely to see large consumer electronic brands dominate the space, potentially alongside large industrial manufacturers. These companies would bring their existing brand strength, customer relationships, route to market, balance sheets, access to cheap capital and purchasing power to the party.”
[Source: Scientific American]

Assuming the analysts have an inside-ear, this means companies such as Samsung, Sony, Phillips (et al) are gearing-up strategies that put them into the solar market within a few years. If so, it marks a “legitimization” of solar energy from a heavily subsidized startup industry to one that is profitable on its own terms. In turn, that implies that solar energy is, or soon will be, competitive with other forms of energy.
More »

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Gene expression and regulation: It’s the location, baby.

Perhaps it is something like the real-estate business. What three things make a difference for selling a house? Location, location and location. Thus it may be for at least some of the crucial genes involved in the development of the human embryo. Specifically, researchers at the European Molecular Biology Laboratory (Heidelberg, Germany) found that the crucial developmental gene Fgf8 is effective not because of the gene itself, but because of its location in the genome. As the study leader, Francois Spitz put it,

“We showed that the surprisingly complex organization of this genomic region is a key aspect of the regulation of Fgf8. It responds to the input of specific regulatory elements, and not to others, because it sits at a special place, not because it is a special gene. How the regulatory elements contribute to activate a gene is not determined by a specific recognition tag, but by where precisely the gene is in the genome.”

[Source: DNA’s twisted communication]

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Inspiration Mars: Suicide gets good PR

It is very difficult not to be cynical about the “Inspiration Mars” project outlined by space pioneer and multimillionaire Dennis Tito. The basic idea is to launch a spacecraft in 2018 with two people in it that will circle around Mars and come back. Easy to describe in one sentence, but…

As just about every commenter and news story relates, one way or another, this is not going to be easy, or safe. For one thing the spacecraft for the mission is not really known. It will presumably be a private vessel, something like the SpaceX Dragon or the Falcon Heavy, but neither are ready for this kind of mission. Then too, there are problems with radiation. I’ve already seen the admission, “If there’s a major coronal mass ejection [sun storm], there won’t be enough protection.” That is, the mission passengers will fry.

Speaking of passengers, the plan is for two people, presumably a middle-age married couple with no children (and no relatives?) who could stand to be locked together in 600 square foot space for 501 days (the duration of the mission). I can hear the late-night comics now.

One other point, the passengers must have enough fuel and supplies to survive the trip and then make a 50,000 mph re-entry into Earth’s atmosphere for a ‘splash down.’

In short, it’s not difficult at all to think of reasons why this might be a suicide mission – and for what? Inspiration?

Yes, inspiration. Just not for a real mission. What, plausibly, are the purposes of this implausible mission:

1. Continual PR for an effort to put human beings on Mars.
2. Fundraising for this and ‘spinoff’ missions.
3. Visibility for commercial space programs.
4. Keep people thinking about space, space exploration, and humans on other planets.

In a way, this strikes me as an extremely contemporary effort, one common to much of politics, business and entertainment. What they say they will do is not what they will actually do, it’s just that a good narrative trumps reality every time.

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New lithium-ion battery: It’s a stretch

flexible battery
Twist, bend and stretch – and store electricity…..credit: J. Rogers, U. of Illinois

In roughly the last decade, there is a substantial research track looking for ways to generate electricity for personal devices, especially those carried or worn such as watches, phones, small computers and the like. The most attractive approach is through piezoelectricity where the contraction or expansion of special materials generates an electric charge. The effort has seen some success:

[SciTechStory: Clothes that generate electric power]
[SciTechStory: Tiny generators for tiny devices]

The basic idea is that movement, such as walking, will stretch and bend piezoelectric material, generating a low but usable amount of electricity. Ah, but there is a rub (pardon the expression). While a direct connection between generating electricity and a device that uses it is workable, it’s not very practical. Most devices need a way to store the electricity. Unfortunately, batteries – at least the kind we’re familiar with – are clunky and inflexible. They’re generally not the sort of thing that is convenient to wear or carry.

That’s where the idea for a flexible battery begins. If people wear clothing that generates electricity, then why not have a battery that can also be part of clothing, something flexible and thin. More »

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ESA is doing something about rogue asteroids

Not long ago Earth experienced a ‘double barrel’ event from the skies, one a tiny ‘rock’ of about 17 meters (50 feet) in diameter that roared overhead in Russia, injuring about a thousand people and doing extensive damage, the other was an asteroid (2012 DA14) whose orbit carried it within 27,700 kilometers (21,000 miles) of the earth surface. [ScitechStory: The Day of the Asteroid and Meteor].

This twofer had the effect of alerting some in the public and a few in media to call for “DOING SOMETHING” about the asteroid menace. All to the good, of course. Unfortunately, in the United States it was generally ignored that the European Space Agency (ESA) already has plans for “doing something,” namely firing two rockets at asteroids to see if the impact has measurable effect.

Today (February 26, 2013) ESA announced that it has picked a target, the asteroid Didymos system, which will approach Earth at a distance of about 11 million kilometers in 2022. Didymos is a binary asteroid system, two asteroids, one 800 meters across, the other 150 meters. Both are much bigger than the two just seen over Earth. As part of the low budget AIDA (Asteroid Impact and Deflection Assessment) program, two small craft will be sent to crash probes on both asteroids. Scientists will study how this affects the orbital dynamics.

This is how we learn about protecting Earth from asteroids – by doing something, in advance.

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Nanobeam: Monitoring cells from the inside

nanoprobe
A nanobeam probe (handle showing) inserted into a cell……credit: Gary Shambat, Stanford School of Engineering

Scientists, like journalists, like to get the inside story. In the case of biologists, it amounts to an unending push to get inside the workings of living things and see what ‘really’ goes on. For example, how great it would be to monitor the changes happening inside a living cell. Unfortunately, it’s been much easier to dream than do. For one thing, most cells are very small – a matter of microns (roughly from 8 microns to about 50 microns, that is, millionths of a meter). Whatever goes into the cell must itself be even smaller, or thinner. Yet how could anything that small still do anything? If it’s too big or in any way destructive – the cell dies. Plus, there’s the added problem of guiding something very small into a cell and finding specific targets.

Historically, observation of cells – living or dead – is a matter of external observation. Essentially that means some kind of device that observes visually (optical microscope), scans with electromagnetism (electron microscope), or prepares the cell in some way to make it ‘visible’ (such as staining). Most of the techniques work, if at all, with dead cells. Living cells, especially in a dynamic (growing) state are much more difficult. More »

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Earth bacteria can survive in a least some Mars conditions

To quote from a movie (Jurassic Park), “Life finds a way.” So far, there is no sign of life on Mars. Water, yes, but not life. At least at or near the surface, Mars is a very inhospitable place for life. It is dry, so dry the Sahara is a sauna by comparison. It is cold, with the balmy days at the equator perhaps reaching 10 degrees Celsius (50F) and most night temperatures in the -60C (-76F) range. Then there is the air pressure, or lack of it. There’s almost no oxygen, of course, and with the extremely thin atmosphere, Mars has almost no barometric pressure. Yet it is conceivable that even under these conditions life may find a way to survive. How do we know this? Two scientists from the University of Florida (Miami) tested extremophile bacteria taken from the artic permafrost and subjected them to Mars environment conditions – and they survived.

In the last decade or two, science has learned a great deal about life – mostly bacteria and viruses – that live and even prosper under incredibly extreme conditions. These extremophiles live in volcanic vents at the bottom of the deepest oceans, in the boiling water of volcanic pools, in rocks kilometers below the surface, in the snow, ice and permafrost of the artic, and at the bottom of permanently frozen lakes in the Antarctic. They live with too much oxygen or no oxygen at all. They consume toxins such as sulfur and carbon dioxide. If these hardy bits of life can live in the least likely places on Earth, could they live on Mars? That’s what the researchers wanted to know.

To test the idea, Wayne Nicholson and Andrew Schuerger with their colleagues analyzed samples of microbes found in the permafrost soil of northeast Siberia (collected by Soil Cryology Laboratory in Russia). The microbes came from borings taken 12 to 21 meters (40-70 feet) into frozen soil (permafrost that never unfreezes). They were placed in petri dishes and grown for 28 days in a nutrient rich and room temperature environment under normal air and pressure. This produced more than 10,000 colonies of bacteria, mostly strains of Carnobacterium, bacteria known to be successful with living in permafrost (and frozen meat). More »

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Brillouin Spectroscopy: Using an old technique to get a new picture of spider webs

Science has known for a long time that spider silk is one of nature’s most fantastic materials – five times stronger than steel, flexible, stretchable to a third of its length, chemically stable. Because of these properties, scientists have studied spider silk for decades and you’d think by now there would be no secrets left. However, it’s still not possible to synthesize spider silk, which means that we don’t fully understand.

Using electron and atomic force microscopes, the structure of individual silk strands is understood to be like a stack of plates or pancakes to keep this organic. Biochemically, analysis showed the layers of spider are beta-sheets of fibroin protein bonded at a very large number of points. The bonds are between hydrogen atoms, normally relatively weak but the vast number results in a very strong bond. This gives spider silk the ability to stretch to great lengths without breaking.

Microscopy revealed at least some of the secrets of spider silk structure, however only for individual strands or a small bundle of strands. Missing was any picture of the structural characteristics of an entire web. The concept of a ‘web’ implies a network of strands each with a function and properties that add up to the properties of the web. There just was no way to measure the forces at work in the entire web.

New research by Kristie Koski and colleagues at Stanford University (Berkeley, California USA) tackled the web problem by reviving the use of an old technique – Brillouin spectroscopy. When a strong light source, usually laser, passes through a medium such as optical fiber (or spider silk), it produces acoustic vibrations. These vibrations alter the composition of the light beam, scattering it usually in opposite directions (Brillouin scattering). The pattern of the scattering can be captured by a Brillouin spectroscope and analyzed for the properties of the medium, in this case, spider silk. More »

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The day of the asteroid and meteor

It certainly grabbed the media’s attention – the meteor that streaked across Russian skies. There was far less attention for the unseen asteroid that slipped by the Earth a few hours later. Still, it was a double feature, two pieces of celestial rock that just happened to cross the path of Earth within a single media cycle.

Did the event, or events, grab the public’s attention? Surely, at least for those with access to the media. Does this attention translate into a desire to ‘do something’ about the risk of a serious asteroid (cum meteor) collision? That’s the question frequently asked by science wonks and those few who know the realities of tracking millions of NEOs (Near Earth Objects). The technical difficulty of tracking 20 meter objects (the piece that fell into Russia) compared to 50 meter objects (the asteroid 2012 DA14 that missed the Earth by a paltry 27,700 kilometers) is not trivial.

The difference is money. Right now, for example, the American space agency NASA spends one-twentieth of a percent of its budget on tracking NEOs. That buys coverage for about 5% of the skies in any one year. Given the current level of technology committed to the tracking project, only objects about 50 meters in diameter or greater have a chance of being spotted. The current flyby of 2012 DA14 was found by pure luck, the meteor was not spotted at all.

Ladies and gentlemen, place your bets! Put your money on tracking NEOs – we may save the Earth (or at least a few lives), or we may spend money with no payback (except, of course, employment and production). Place no money and take the bet that nothing really bad will happen, and we could spend all that saved money on something more tangible like a fleet of domestic drones.

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Sci-Fi Movie Review: Prometheus

[Prometheus. Released June 2012. Directed by Ridley Scott, Writers John Spaihts and Damon Lindelof. DVD/Blu-Ray released. As usual, this “post-viewing review” contains many spoilers.]

The opening scene of Prometheus, which demands interpretation right out of the reel, is of a humanoid alien imbibing some kind of nanotechnology that transforms him (it?, there seem to be no females) into a cloud of particles that spill into the ocean, turn into DNA molecules and presumably ‘seed’ the human race. (See Science Spoilers below.) I don’t know how many people will understand the scene, but for sure, it is portentous.

In fact, Prometheus is a movie with portentous overload. It’s about nothing less than the origin of the human species – and one other species with a telescoping dental apparatus. It’s ‘about’ many other things, depending on the interpretation. That’s why the movie is portentous, in this case meaning ominously significant; it demands interpretation, even while you’re watching. Put in other terms, it’s a dark-toned ‘heavy’ film in both mood and content, which will not appeal to someone looking for, say, the flash and excitement of the J.J. Abrams Star Trek. More »

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Overcoming mitochondrial diseases by having three parents

Whenever I hear about mitochondria, I think of midichlorians, “the force” of John Lucas’ Star Wars, the life energy that binds the universe by being part of every living thing, but especially concentrated in Jedi…and Sith. I don’t know if knowledge of mitochondria inspired Lucas, but there are strong parallels to midichlorians. Mitochondria are part of almost every animal (eukaryote). They are organelles, small organ-like components of the cell. In this case, mitochondria are the ‘power plants,’ their chief function being the transformation of sugars and other materials into adenosine triphosphate (ATP), the energy source (the force) of the living cell.

The thing about mitochondria is that they’re not native. They didn’t evolve from the primordial eukaryote. Mitochondria were incorporated or possibly implanted from bacteria. The mitochondria in our cells have their own DNA, limited to be sure, but still a complement of thirty-seven genes. They also have RNA and in some respects develop as if they were a separate cell or, shall I say, life form. That’s because they probably were. For now, most biologists believe today’s mitochondria are the evolutionary result of the primordial incorporation of a bacterium probably 1.7 to 2.0 billion years ago. Whether it was by incorporation, where the host cell took in the mitochondrial bacteria, the bacteria invaded the host cell, or some kind of symbiotic combination that simply joined and then evolved – is unknown. More »

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Armstrong: One small step for a man

“Damn I really did it. I blew the first words on the moon, didn’t I?” So said Neil Armstrong (1930-2012) to the authors of the 1986 book Chariots of Fire. It seems so characteristic of the man, to admit his human frailty concerning something so immortal as his famous line: “That’s one small step for man, one giant leap for mankind.” Fifty-thousand years from now, if the human race is around or relevant, Armstrong and that line will still be remembered. Only it should have been: “That’s one small step for A man, one giant leap for mankind.” It changes the meaning, in a way. But we get it. The first man on the moon. A simple step off the bottom of a ladder for Neil Armstrong, decades of work – if not the whole of human history – to get him to the moon in the first place. Now that’s a real moment in history, and in what seems to be typical Armstrong self deprecation, he admitted that though he wanted to say “a man” it didn’t come out that way. Human beings are really like that. They make mistakes, big and small. Armstrong was very much a human being, among the best. We should rejoice in what he was able to do and that Neil Armstrong was the one to be the first man on the moon.

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Curiosity has just begun

About a quarter million people were watching NASA TV as the Mars rover Curiosity was put down on the surface of Mars. Not bad for 1:30AM on the east coast of the U.S. The room at JPL mission headquarters exploded with shouts, cheers and cries of joy. Of course, these men and a few women were well aware of what was just achieved: The most complex landing procedure of electronic and mechanical equipment ever attempted at such a great distance (roughly 154 million miles/248 million kilometers). Then there is the US$ 2.5 billion invested and the badly needed prestige for NASA. It was a high profile, high stakes effort – and it has succeeded in the first big step.

Landings on Mars are never taken for granted. In fact, so many missions have failed that there was talk of a ‘Mars jinx.’ That implies bad luck, when in fact, luck has had very little to do with it. As the Curiosity landing demonstrates, even the most complex landings are possible, as long as the technology and the planning are right. In short, human effort, and very little luck determines whether a mission like this works or not. So kudos and appreciation for the people who made this possible. Earth has a new ambassador on Mars, the most sophisticated probe/rover so far assembled.

Curiosity will now begin its two year movement around the surface of Mars, as it coordinates its research within the Mars Science Laboratory project. With all the hoopla, it’s easy to momentarily underestimate the work that remains to be done. The rover’s mission is to study Mars for human habitation including its climate and complex geology – and, by the by, look for signs of past or present life on Mars. This is research that will take some time to unfold, but when the excitement of the landing is long forgotten, this is what Curiosity is all about.

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Fetal DNA sequencing: Reading ma and pa’s genome

Depending on how successful interpretation of the personal genome becomes, any method that makes the process easier for collecting the DNA is progress. That’s one way of saying that the future of personal genome medicine depends on the research that finds the links between genes and disease, and how easy and inexpensive it is to get a personal genome reading. One obvious trend is that the equipment for DNA sequencing continues to become less expensive and more powerful, something like the progression followed by computers over the last decades. Research continually finds links between specific genes and human health problems, although the validity of the interpretations (cause and effect) is in dispute. Now a new collection technique promises to make analysis of fetal DNA easier and less problematic.

The approach, developed by Jacob Kitzman and Matthew Snyder at the University of Washington (Seattle, USA), uses a sample of maternal blood taken at about 18 weeks into a pregnancy and a sample of paternal saliva to do genome sequencing and then run the combined genomes (mother, father, fetus) to make a composite and highly accurate reading of the fetus’ genome. More »

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