More molecular medical delivery

One of the most important areas of nanotech research and development is the area of nanoscale delivery systems for drugs and genetic material. Advances occur frequently. Here’s another one:

Theresa M. Reineke, associate professor of chemistry in the College of Science, and colleagues in her lab at Virginia Tech and at the University of Cincinnati have developed a new molecule that can travel into cells, deliver genetic cargo, and packs a beacon so scientists can follow its movements in living systems.

The scientists created novel polycations. A polycation is a polymer chain with positive charges, which is not too unusual. DNA itself is a polyanion, a polymer with negative charges. However, the Reineke Group’s supramolecule has options. It contains chemistry (oligoethyleneamines) that binds and compacts nucleic acids – pieces of the DNA – into nanoparticles. It also incorporates a group of rare-earth elements known as lanthanides. The repackaged DNA is protected from damage as it travels into the cells and the lanthanides allow visualization of the delivery into cells.

[Source: Eurekalert: Biology]

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