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Plasmonic nanostructures make graphene viable for super-fast communications

On the one hand graphene, a single layer of carbon atoms in a honeycomb pattern, can move electrons (electricity) very fast and efficiently. On the other hand graphene is lousy at absorbing energy, specifically from sunlight; only about 3% is absorbed. Sounds like graphene, a wonder material in many accounts, isn’t cut out for solar cells or photonics (such as communication by light). Well by itself it’s not, but graphene is such a tempting material that clever minds are set upon making it do all kinds of things it doesn’t appear to do. In this case, among the clever minds are the two fellows who won the Nobel Prize for their work with graphene, Andre Geim and Kostya Novoselov plus their team at the University of Manchester, and Cambridge University (UK). Their newest work, published in the journal Nature Communications [30 August 2011, paywalled, Strong plasmonic enhancement of photovoltage in graphene] advances the use of graphene.

Their approach to making graphene part of a photonics system, where it contributes higher speed transmission, is to put closely-spaced nanoscale metallic wires (nanowire) on top of the graphene layer. The wires, called a plasmonic nanostructure, can take on a large variety of shapes with exotic names such as nanoshells, nanomatryushkas, and nanorice. The shapes (structures) of wire are significant because of what they do to incoming light energy – they, in effect, bend, reflect and transform it so that, in this case, far more energy is absorbed by the graphene layer. In fact, it boosts the absorption efficiency by about twenty times, a rather remarkable figure. More »

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A keystone discovery: Proteins and synaptic vesicles

It happens quite a lot in neuroscience that something can be described without really knowing why it’s doing something. Bear with me a bit, as what I’m about to describe is probably unfamiliar to most people and also very much concerns the nitty-gritty of how the cells (neurons) of the brain and nervous system work.

Neuroscientists have known for some time that nerve endings near the critical junction points between nerve cells, the synapses, are filled with tiny sacs (like microscopic bubbles) containing chemicals called neurotransmitters. Neurons work by sending a pulse of electro-chemical energy along the length of the cell (through nerve fibers of the axons) until it reaches a synapse – a gap between the end of one neuron and the beginning of another. For the pulse to cross this gap it must trigger the release of neurotransmitters stored in vesicles (those tiny sacs) that cross the gap. Depending on how much and what kinds of neurotransmitters are released, they may fire triggers in the next neuron and so the nerve impulse passes on, from toe to brain in some cases. This is not, as you can tell, the convenient metaphor of an electrical charge travelling down a wire. We are not ‘wired,’ actually; it’s more like tenuously and conditionally connected, something like your computer connected to Wi-Fi.

This is not the most efficient or high speed way of transmitting an electrical signal (parenthetically, some types of neuron actually do act like an efficient ‘wire’); so why are most neurons set up this way? That’s one of the big questions in neuroscience. I mention this because it’s also been clear for some time that the function of the synaptic vesicles and their neurotransmitters is to ‘filter’ or ‘weigh’ the meaning or importance of a pulse coming across the synapse. More »

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lincRNA: A recently discovered RNA organizes stem cell differentiation

What makes a scientist’s heart go pitter-patter? Something like this:

When the Broad team discovered more than 3,500 unique lincRNAs in the human and mouse genomes in 2009, “the potential was enormous, and we wanted to know what they could be doing.”

[Source: Technology Review]

Here’s the scenario: A team of researchers at the Broad Institute (a joint operation of Harvard University and Massachusetts Institute of Technology, USA) discovered in 2009 that human and mouse genomes were encoded to produce thousands of a hitherto unknown form of RNA. The role of RNA, as commonly understood, is to carry the genetic code for protein production from the DNA to the locations of protein manufacture. Over the years, however, new forms of RNA were discovered – microRNA, mRNA, siRNA, RNAi, among others – and the range of function for RNA extended. In fact, the team at Broad Institute had discovered a form of RNA that didn’t appear to have any role in the coding and manufacturing of proteins. Called a lincRNA for ‘large intergenic non-coding RNA’, this form of RNA was found in all cells in great numbers. The team eventually identified over 3500 unique forms of lincRNAs. The question staring them in the face and making their adrenalin pump (so to speak) was, of course, what do all these lincRNAs do? More »

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Posted in News: Proteomics | Tagged , , , , , , , , , | 1 Comment

Supersymmetry: SUSY still has no data

Even physicists get that sinking feeling in the pit of their stomach that something you’ve relied on for most of your life may be wrong, or at least not as right as you thought. If you’re a good scientist, you question and examine – your own thinking and whatever it is that has shaken you so badly; then perhaps you suck it up and move on. So it may be for physicists and cosmologists who believe in the theory of supersymmetry.

It would be futile in a blog entry to attempt a satisfying description of supersymmetry and its relationship to the Standard Model of particle physics. Anyway, this piece is about scientists reacting to new information, not about the inner workings of the theory. Still, for convenience: supersymmetry, often shortened to SUSY, is a theory that relates to symmetry between certain elementary particles that are similar to those in the Standard Model but have different characteristics – so called superparticles. Symmetry for these superparticles consists of having for every type of boson a corresponding type of fermion. This relationship forms what are known as superpartners. Superpartners are not considered to belong to the Standard Model of physics.

Supersymmetry was developed in large part to deal with certain problems in the Standard Model. For example, the problem that there is more matter in the universe than we can detect – the problem of so called dark matter. Supersymmetry provides the existence of superparticles to explain dark matter. It also can explain the Higgs boson and some aspects of cosmology. As many a physicist will tell you, SUSY is a lovely theory, earning the high praise of ‘elegant.’ Just one problem, a big one: There is no evidence that superparticles exist. More »

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Synthetic biology: Making new proteins with E. coli by adding DNA

Sometimes big advances in science happen without much public notice. That’s often because at the time they didn’t look like big advances in science, or just as likely, they were considered marginally workable, so nobody wanted to highlight them. Here’s one such case to consider: Researchers at Yale University (Connecticut, USA) and publishing in the journal Science [26 August 2011, paywalled, Expanding the Genetic Code of Escherichia coli with Phosphoserine] have announced the use of synthetic biology techniques to add new DNA to an old friend of the lab, Escherichia coli (E. coli). The new DNA does something never done before: It produces new forms of proteins with the ability to phosphorylate.

I can see the “?” form over your head. I’ll explain in a bare moment, but first the “Why?” Using the new DNA, biochemists will be able to create proteins that mimic disease conditions, or components of diseases – and turn them on or off as part of experimental testing. Doing this should give scientists much greater insight into the role of proteins in diseases and how to control them. In short, it creates a kind of ‘sandbox’ (controlled) environment to test hypotheses about diseases and how they work. Now, for a bit of explanation… More »

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IBM doesn’t call it a brain chip

IBM calls it a neural core, not a ‘brain chip’ or a ‘thinking chip.’ The recently announced development involves two prototype chips that contain circuitry inspired by biological components of the brain – neurons, synapses and axons. The chips are the earliest building blocks of what IBM hopes to develop into a more complete system – a cognitive computer.

Believe me, if this information is all you’ve heard or remembered (if, of course, you’ve seen anything at all); you’ve just caught sight of the first icy pinnacle of the above water iceberg.

As is typical, what gets the most attention is the thing someone made, in this case the neural core chips. In this case, that misses something far more important – the history and progress of a specific research unit within IBM, the Cognitive Computing group, and its chief scientist, Dharmendra Modha. The neural core chip isn’t some one-off research product; it’s a component that researchers decided was necessary to make progress in a massive research program that began in 2006. Funded to the tune of many tens of millions of dollars [most recently$21 million by the Defense Advanced Research Projects Agency (DARPA) for Phase 2 of the Systems of Neuromorphic Adaptive Plastic Scalable Electronics (SyNAPSE) project], the Cognitive Computing group encompasses the efforts of IBM’s Almaden Research Center, IBM’s T. J. Watson Research Center and five academic institutions (Columbia University; Stanford University, Cornell University; University of California, Merced; and University of Wisconsin, Madison).

The Cognitive Computing group first made news in 2007 with a mouse-scale brain simulation, followed by a rat-scale brain simulation, then in 2008 a cat-scale brain simulation and finally a simulation of a monkey brain. At each step the simulation required a much bigger supercomputer and it became apparent to the researchers that a traditional computer with enough power to achieve a human-scale simulation would require so much energy, it would probably incinerate itself. Yet the human mind doesn’t (usually) incinerate, in fact, it operates rather nicely at about 10 watts, a rather dim bulb. Modha and his team came to realize that if computers were going to achieve human level mental complexity, they too would have to use less energy. This demanded a different model of computing, hardware and software, than the current mainstream (von Neumann) computers. The new model, as expressed by the tiny, low power building blocks of the neural cores is the cognitive computer. More »

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Micromold technology: New technique for fabricating cells and tissues

As they say, there’s more than one way to skin a cat. Perhaps they should also say, there’s more than one way to make a cat skin. One of the key objectives of synthetic biology is to create materials that can imitate the functions of cells and tissues, like creating the building blocks of biological material that can eventually be used to engineer organs – like skin. This is a very active area of research with many approaches in development. You’ll see references to new materials that can encapsulate and deliver drugs or microparticles that are used to make biological ‘scaffolds’ for the construction of tissue. [SciTechStory: Making a start on a synthetic liver] A new approach, developed by researchers at MIT (Massachusetts Institute of Technology, USA) and published in the Journal of the American Chemical Society [18 July 2011, paywalled, Responsive Micromolds for Sequential Patterning of Hydrogel Microstructures] brings microparticles for drug delivery and synthetic organs together through the use of micromolds. More »

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New evidence for liquid water on Mars

Liquid water on Mars
The possible seasonal rills of running water on Mars……Credit: NASA, JPL

Earth has lots of liquid water, like oceans of it – though salty. Why would people be excited by briny water on Mars? However, for those intrepid, dreaming human beings who think of traveling to Mars and one day pitching camp there, the news from the NASA Mars Reconnaissance Orbiter (MRO) and reported in the journal Science [04 August 2011, paywalled, Seasonal flows on warm Martian slopes] is almost surprising: There may be, at times, running water on Mars.

Far and away most of the Martian planetary surface is too cold for water, liquid or frozen. With a mean temperature of -63 degrees Celsius, surface water or ice quickly sublimates in the cold dry atmosphere. It has long been thought, and then shown by satellite instruments, that water exists on Mars but only as subsurface ice. Now it looks like there may be exceptions. More »

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The Big Splat: New two moon hypothesis

It doesn’t sound very scientific, but some scientists are calling it the “Big Splat.” That refers to the results of a new computer model showing the early Earth having two moons that collided. Planetary scientists Martin Jutzi and Erik Asphaug at the University of Southern California, Santa Cruz (USA) and publishing in the journal Nature [4 August 2011, Early Earth may have had two moons] have constructed a classic example of a testable scientific hypothesis that fits the known facts.

It’s been known for decades that there are striking differences between the surface of the Moon on the near side (the side we see from Earth), which is relatively smooth, low and flat, and the far side, which is high, mountainous and has a much thicker crust, about 50 kilometers (30 miles) thicker. It’s also widely accepted that something about the size of Mars slammed into the Earth about 4.5 billion years ago and ejected material that eventually coalesced into the Moon. The new hypothesis, as simulated by computer, proposes that two moons were created at about that time with the second roughly 1/30th (about 4%) the mass of the larger moon. The second moon shared the same orbit for about 100 million years but at some point it collided – not with a huge high velocity bang, but more likely a slower velocity “splat.” More »

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Guanfacine: A possible drug to improve memory in old age

As you get old, you start to forget things. True. Not that you couldn’t forget things when you’re younger and distracted; but as you get older, perhaps you’re more easily distracted. Why would that be? There are many lines of research into the loss of memory capacity as we age. One such line is conducted by Amy Arnsten and a team of researchers at Yale University (New Haven, Connecticut, USA). Their work concentrated on the so-called ‘short term memory’ capacity of the pre-frontal cortex, that region of the brain most associated with moment-to-moment (real time) higher level mental activity. Using a variety of animals at various ages (young, middle aged, and elderly), they tested for firing rates in the pre-frontal cortex while the animals underwent working memory tasks. The results, reported in the journal Nature [27 July 2011, paywalled, Neuronal basis of age-related working memory decline] showed that as the animals age, the rate of neuron firing declines – which implies a loss of memory capacity. More »

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Promising new material: Electronic and optically active photonic crystals

Although it’s not as tricky as producing new drugs for medicine, developing new materials for commercial electronics is usually no sure thing. There is a long path of testing and development between the first prototype material and something that can be manufactured in large quantities and used in a variety of products. On top of that, there are usually many competing new materials with similar or sometimes even identical properties. In electronics, for example, graphene transistors, spintronic semiconductors and various memristor approaches all vie for the commercial jackpot. To that list can now be added photonic crystals. More »

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Epigenetic memory: Another path for genetic inheritance

As we have all been schooled, DNA determines what is inherited. If it isn’t encoded in the genes, it won’t be passed on. Except it is becoming ever more apparent this isn’t completely true. There is another way that characteristics can be passed to the next generations; it’s called epigenetic memory. Or at least it’s called that in a research paper from Martin Howard and Caroline Dean at the John Innes Centre (Norwich, UK) and published in Nature [24 July 2011, paywalled, A Polycomb-based switch underlying quantitative epigenetic memory]. Their research indicates that certain histones, the material that encases and configures the shape of DNA, can position genes to turn them on or off in response to short-term environmental conditions, and that these configurations are not only passed on to new (daughter) cells, the common process of epigenetics, but can also be transmitted through gamete (egg and sperm) cells as a true generational inheritance. More »

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Epigenetics and methylation: New DNA bases linked to protein

Adenine, thymine, cytosine and guanine: These are the nucleobases, or just plain bases of DNA that in pairs called nucleotides carry the genetic code of life. There are four of them, right? At least that’s what most everybody learns. Of course, there is another base, uracil, which is found in RNA where it replaces thymine. But wait, there’s more. More bases that is, or at least that’s what biochemists call them, although their names are unfamiliar. In fact, now there are four of them: 5-methylcytosine (first discovered), 5-hydroxymethylcytosine, and most recently 5-formylcytosine and 5-carboxycytosine. These last two were finally reproduced in the laboratory by Yi Zhang and team at the University of North Carolina (USA) in Science Express [21 July 2011, paywalled, Tet Proteins Can Convert 5-Methylcytosine to 5-Formylcytosine and 5-Carboxylcytosine].

It seems pretty obvious that these new bases 5 through 8 are not replacements for the more common four. So what’s the deal, why are these unmemorable variants of cytosine important?

They are the result of a process called methylation. In DNA methylation is a chemical process that adds an organic molecule, a methyl group with a basic formula of CH3, to the base cytosine. When a methyl group is tacked onto a nucleotide, it changes its characteristics, namely the configuration or shape. Simply put, it causes that portion of the double helix to fold into itself. This shields the underlying nucleotide from activation – in short, it’s turned off. Most of the human chromosome available for methylation has been turned off in this way. Where they are not turned off, that’s where a very large percentage of genes are ‘expressed’ – involved in producing protein. More »

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Space Shuttle Atlantis: happy landing, and out with a whimper

Among the many things said and written about the ending of the American space shuttle program, one thing we are not likely to hear any time soon is the last word. In short, it’s going to require the perspective of history, probably fifty years, before the impact of the space shuttle program – operating, then not operating – will be understood in the broad context of human space exploration.

Those things that can be said now, have been said, endlessly. I don’t pretend that among the few thoughts offered here there is anything new. It’s just that, like so many people, I grew up with the Apollo space program that put Man on the Moon, and the shuttle program that put up a permanent station in space. It seemed reasonable to believe that humans venturing into space were just part of the natural progress of the world.

Then over the years I learned something: Space exploration is roughly two-thirds politics. (I already knew there is nothing very natural about politics.)

It’s two-thirds politics because somebody has to pay for space exploration. Space exploration, especially manned space exploration is, to no surprise, very expensive. It is not only expensive but in all honesty with manned space exploration there is relatively little payback. It is so expensive and unprofitable that for the most part only governments have the money for it – if they have the money for it at all. That’s where the politics comes in. Space exploration from the beginning had to compete with other uses of government money. Typically a relatively large chunk was available for military space projects, almost all unmanned. This is not only true for the U.S. but also China and Russia. The non-military chunk of money depended on general budget allocations, which in turn depended on the political clout of the principle contractors that benefited from space exploration. This was and is a natural field for political sensitivity to economic conditions, bureaucratic infighting, and geopolitics. More »

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Toward a new DNA: thymine out, chlorouracil in

Scientists have been twiddling with DNA for some time. While DNA may be the blueprint of life, it is not immutable (of course) and that means the hand of man likes to poke around in the mix. One kind of poking has been to see if one of the bases – adenine (A), thymine (T), cytosine (C), and guanine (G) – that make up the genetic code can be replaced. If it could be done while keeping the subject alive, it would constitute a new form of life.

This ‘swapping of bases’ is a trick that nature might have done. Last year (2010) there was a relatively well publicized rhubarb among scientists about the discovery of arsenic life by a team of NASA funded researchers. They believe(d) they found a strain of bacteria living at the bottom of Mono Lake in California that due to a lack of phosphorus had substituted arsenic for phosphorus in key biological compounds (not in DNA but in ATP). [SciTechStory: An odd couple: Arsenic and life] The claim for arsenic life did not hold up too well under close scrutiny, but the mechanism at work, an evolutionary chemical substitution, is relevant to the current story.

In this case, an international group of researchers (Germany, USA, France, Belgium) looked at the structure of DNA and decided that if any base could be substituted, it would be thymine. (RNA already uses uracil instead of thymine.) They reckoned that 5-chlorouracil was chemically and structurally close enough to thymine to – perhaps – be taken up by DNA. Thus they began their experiments with the labster’s favorite bacteria, E. coli, by essentially putting it on a diet of nutrient spiked with chlorouracil and continually lowering the amount of thymine available. More »

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Memflector: Neuron-like computer component

I try not to put too much weight on very early advances in technology. This is particularly true of computer technology because there are so many relatively new avenues of research, all clamoring for attention: Quantum computing, DNA computing, optical computing…etc. On the other hand, computing has become so vital, especially for science and business, that it’s important to keep a hawk’s eye view of the entries into the field. So here’s another – phase-change computing.

The basis of this approach, phase-change materials (PCM) is not new at all. Solid, liquid and gas are the phases of most materials, for example, H2O – ice, liquid water, water vapor. As the materials pass from one phase to another (solid-solid, solid-liquid, solid-gas, liquid-gas) they give up or store heat. Some materials exchange more heat energy than others and those are the ones identified as phase-change materials. For example, salt hydrates, fatty acids and various paraffins are PCMs and have been used to store heat since the late 1800’s.

It’s the property of dramatically changing energy level that interests computer scientists. A phase-change material that starts at one low energy state (0) and after an electrical charge has a detectably high energy state (1) can be the basis for a memory storage device, or a calculation register. These are the basic components of a digital computer, and that’s why PCM materials are on the way to use in commercial memory devices. What is relatively ‘new’ is the attempt to use PCM materials that in some rudimentary way emulate neurons (brain cells). More »

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Neuroscience: Memory tied to a specific protein complex

At times it must seem to neuroscientists that the enigma of memory reveals its secrets to them as if they were the proverbial blind men describing an elephant. “Ah yes, it has a hose, a very thick hose, so thick it’s almost like a tree trunk!” If only it were as easy to get the feel of neurons as it is for an elephant.

Philosophers and scientists have been pondering, poking and experimenting around the concept and physical reality of memory for centuries. Saying, “We’re a lot closer now,” is probably true, but like determining the properties of an elephant, what we know is probably bits and pieces. That said, as new pieces are added, something that resembles a working hypothetical framework is emerging, and science thrives on frameworks that answer questions and lead to testable results.

A new piece, and potentially a very important new piece, has been added by John Lisman and Zalman Kekst at the Lisman Laboratory at Brandeis University (Boston, Massachusetts, USA) and published in the Journal of Neuroscience [22 June 2011, paywalled, Role of the CaMKII/NMDA Receptor Complex in the Maintenance of Synaptic Strength]. In short, memory appears to be related to proteins that exist in the unique space between neurons called the synapse.

The finding, which I’ll describe in more detail in a moment, is not in itself surprising. Neuroscientists have suspected for some time that proteins are involved in the memory process. It figures, because proteins are the ‘building blocks of biology.’ They are the most flexible, adaptable, and varied of all the biochemical materials. Why wouldn’t memory, which probably requires trillions of coding possibilities, make use of proteins? Well, it hasn’t always been seen that way. Among the many models of how memory works, it was held for some time that neurons themselves, brain cells, were created, shaped and connected to create memory. That model is in the process of being superseded by findings that indicate memory is more likely created in the synapses between neurons. More »

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Salt water ocean on Enceladus

It could be called the briny deep, but that might be pushing it a little. Nevertheless, a new study confirming a salty ocean under the icy surface of Saturn’s moon, Enceladus, is significant. Further analysis of data from the Cassini space probe led by researchers at the University of Heidelberg (Germany) and the University of Colorado, Boulder (USA) and published in the journal Science [23 June 2011, paywalled, ] indicates the presence of large salt crystals that are ‘squeezed out’ by freezing water vapor that jets into the super-cold Enceladus atmosphere. The reasonable explanation for the salt is the existence of a large saltwater ocean. The scientist hypothesize that Enceladus has an ocean between the 50 mile (80 km) thick top layer of ice and the rocky core of the moon. The rocky core is deformed by the shifting gravitational pull of Saturn, which produces the heat necessary to keep the water from freezing.

It’s not much of a mental stretch to understand that a ‘relatively warm and salty ocean’ might be an environment favorable to life. We know of one such place already. The confirmation of a salty ocean on Enceladus also raises the possibility of many more such moons elsewhere in the cosmos, thus upping the probabilities for locating exogenous (non-Earth) life.

Related Posts:
[SciTechStory: Ocean on Enceladus has a built-in heater]
[SciTechStory: Enceladus has at least a sea, possibly life]
[SciTechStory: On the Moon or elsewhere follow the water]

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Fluorescence microscopy: Scoping out molecular immune mechanisms

Science and technology have long danced together. Until somebody built a telescope, the moons of most planets were invisible. The impact of the microscope was even more telling. This relationship continues and it’s useful to occasionally dip into the flow of scientific discovery to recognize just how much of it relies on advances in technology. Case in point: Researchers at the University of New South Wales (UNSW, Sydney, Australia) have been able to observe the live functioning of T-cells, the front-line immunity mechanism of the body, with the aid of a super-resolution fluorescence microscope – one of only six in the world. More »

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Supercomputer race: Japan’s Fujitsu takes the lead

The bragging rights for building the world’s fastest supercomputer pass to Japan and Fujitsu’s K-supercomputer. For most people this is a fleeting tidbit of technology news, but it is one kind of milestone marking the increasing power of computers. For the computer industries in the countries involved, it is a rather big deal. In this case, the manufacturer is a private company not a government agency or academic organization, which is somewhat unusual. Fujitsu may not directly profit from the K-supercomputer itself, but in the commercial world bragging rights can be mighty influential. Just ask IBM.

The ‘numbers,’ always important in supercomputer contests, are impressive: The old champ, China’s Tianhe 1a, managed 2.507 petaflops. [SciTechStory: Tianhe 1a: China and the world’s fastest supercomputer] A petaflop is a thousand trillion floating point calculations per second. The new champ can do 8.2 petaflops. This is a smashing win. To achieve this, Fujitsu used 68,544 SPARC64 VIIIfx CPUs with a total of 548,352 chip cores – double the nearest competitor. The performance is roughly equivalent to a million desktop computers connected into one system. Only, of course, a million desktop computers would never perform like this. Truth is, the secret to a super-fast supercomputer is software, specifically hyper-specialized forms of network software. That’s where Fujitsu has taken the lead. Developing this kind of software is a monumental intellectual and practical task where even the most minute inefficiency in the programming can cost gigaflops.

The race continues, of course. Three U.S. computers (Oak Ridge National Laboratory, Cray, and IBM) have already been announced as 2012 entries that are expected to achieve about 20 petaflops and China is not sleeping.

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State of the oceans: Degrading faster

IPSO expert panel
International Programme on the State of the Ocean expert panel…Credit: IPSO

The ocean big and wide and mighty…is damaged, seriously damaged. How to get that message across in an era when so much propaganda is directed toward destroying the credibility of science? For years scientists have been warning that the oceans are degrading – acidification, warming, overfishing, pollution – each in turn has been studied and found to be a threat. It seems like crying wolf (or shark!), when everybody would prefer to ignore it.

Now along comes the International Programme on the State of the Ocean (IPSO), which put together a workshop and report summary for release 21 June 2011: International Earth System expert workshop on ocean stresses and impacts and they say ocean life is “at high risk of entering a phase of extinction of marine species unprecedented in human history.” In short, the state of the ocean is worse than previously thought.

An expert panel of 27 scientists, drawn from many ocean and marine specialties, examined and discussed research across the board of the many challenges to the health of the ocean. The challenges are not new: A growing acidification of many areas in the ocean that affects many forms of marine life, a rise in ocean temperature due to global warming, increased pollution in various regions, and overfishing with drastic reduction of fish stocks throughout the ocean all play a role; but the important news is that taken together the changes in the ocean are happening much faster than was thought. More »

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BioBolt: A semi-invasive skull implant

BioBolt
BioBolt on a primate cranium….Credit: Euisik Yook, U. of Michigan

The idea of a ‘brain implant’ bothers people. It even bothers scientists, since brain implants invade the tissue of the brain (always a delicate operation) and because to function properly the skull must remain open while the implants are in place. This makes it difficult to use implants anywhere but in a hospital or laboratory environment. One approach to the problem has just entered the patent approval stage; it’s called BioBolt, the product of research by Euisik Yoon and a team at the University of Michigan (Ann Arbor, USA).

At heart, the BioBolt is an advance in Brain Computer Interface (BCI) technology, a field of research that attracts attention for a surprising variety of applications including neurological research, medical prosthetic control, psychological palliatives, and game control. There are many approaches to BCI, of which BioBolt is one. It’s small enough, about the size of a small button, to fit in the skull bone and under the skin, where it is not a threat for contamination. It offers contact with the surface of the brain for higher resolution monitoring without the dangers involved in brain tissue invasion. Its chosen form of communication, through the electrical pathway of the skin, sounds like science fiction but is a relatively well researched approach. More »

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Graphene ICs: IBM builds graphene transistors into a circuit

About one week before IBM celebrated its 100th year, IBM researchers published in the journal Science [10 June 2011, paywalled, Wafer-Scale Graphene Integrated Circuit] and publicly announced the design of a high speed graphene circuit. Since there are announcements about this or that new application of graphene just about every week, it would be easy to take the IBM announcement in stride and basically ignore it as a run-of-the-mill piece of science or technology. That would be a mistake.

Three words stand out that elevate the importance: graphene, circuit and IBM. Graphene as you probably have heard by now is the non-new pure carbon material with unsuspected properties that were, in part, made practical to the world of research as recently as 2004 (and resulted in a Nobel Prize for the effort). Since then, the pace of research and application development has been nothing short of astonishing. Significantly, one of the leaders in that research has been IBM. [SciTechStory: Graphene transistors] IBM was among the first to produce a working transistor using graphene (2009-2010), which at the time was considered difficult because graphene is not naturally a semiconductor (unlike silicon, for example). However, even the first working graphene transistor IBM built was already twice as fast as a comparable silicon transistor. That meant full speed ahead, in more ways than one. More »

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IBM at 100

Today (June 16, 2011) is the 100th birthday of IBM. There will be parties, almost all of them provided by IBM for employees. I suppose a few competitors, past and present will raise a thought for IBM. I’ve seen a few articles about IBM’s 100th in prominent publications. A few bloggers will have their say. Then business goes on.

That’s a fair and proportionate response. As a business, IBM can afford its own promotion, and though conservative in tone it doesn’t shy away from reminding people (especially customers) of all the wonderful things IBM has invented and produced in the last 100 years. After all, it is no small achievement that the three letters, IBM, are all but synonymous with computing.

When I write science fiction set in the near future (say a hundred years out) and I want to refer to a company that manufactures something related to computers, the first name that pops into my head is almost always IBM. I’m sure I’m not alone in this. Of course, I may not use the name IBM, after all who knows if it can possibly survive another hundred years? But of all the technology companies, most of which come and go surprisingly quickly, IBM has earned a special position through its longevity. More »

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Human genetics: The mysterious unequal mutation by sex

By the numbers, geneticists thought about mutations like this: There are six billion pieces (nucleotides) of genetic information in the genome. Three billion provided by the mother and three billion from the father. Based on evolutionary studies, previous estimates reckoned about 100-200 mutations would be passed on to each child. It was assumed that because the male genome is copied millions of times during the creation of sperm, compared to the tiny number of eggs produced by the female, most of the mutations would be coming from the father. Apparently not. More »

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