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New elements: ununquadium (114) and ununhexium (116)

Since it doesn’t happen very often, it’s worth noting that two more basic elements of the universe were added to mankind’s chart of such things, the periodic table of the elements. Don’t be put off by the unun, that’s just a placeholder prefix for an element admitted to the periodic table of elements that doesn’t have an official name.

The Joint Working Party on the Discovery of Elements has studied evidence accumulated by the Joint Institute for Nuclear Research in Russia and the Lawrence Livermore National Laboratory in the U.S. since 2004 from particles observed after smashing calcium nuclei (20 protons) into curium nuclei (96 protons), which produced an element with 116 protons (ununhexium) that immediately decayed into an element with 114 protons (ununquadium).

These two particular elements (pun intended) don’t stick around long, just a few femtoseconds, and so far scientists aren’t able to detect anything ‘useful’ but this kind of smashing success moves particle physics down the road toward understanding the behavior of the atomic nucleus. Also down the road, around element 120 (if it can be produced), physicists predict that an ‘island of stability’ will be reached where the newly constructed elements might persist long enough to be useful.

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DNA Computing: Advances in organic circuits

DNA computation
DNA logic gate components……Credit: Royal Publishing Society

Let’s come at computers from a different angle for a moment. An alien species lands on earth. Their spaceship doesn’t look like a spaceship. It looks like a very large blob, of sorts. It’s a blob because the whole thing is organic, not a scrap of metal on it or in it. The aliens are, of course, also organic. Their entire technology uses only organic compounds, as we call them (praise be to carbon). That means their on-board computers are also organic. No silicon chips. In fact, they don’t even use graphene, which is pure carbon but not organic. Instead they use computers based on DNA and related substances, which with minor variations is almost the same as our DNA. They have used DNA because on their long voyages through space only DNA is self-perpetuating, self-repairing. Their computers get old, but a new crop is always in preparation. Their organic computers are infinitely recyclable and require only the minimum of manufacturing capability.

Okay, that’s science fiction. Computers based on DNA are not science fiction, quite. Biologists and computer scientists have been attracted to the notion of using the combinatorial power of DNA to perform computer-like calculations for decades. It’s fair to say though that moving from what seems to be a logical use of DNA to the actual biological material has not been easy. No human made ‘biological computer’ exists; the problems are far too complicated. These days what most scientists choose to do is work on something comparatively simple – logic gates, the basic computer component, built from DNA.

Lulu Qian and Erik Winfree with their team at the California Institute of Technology (Caltech, Pasadena, USA) built the first such logic gate, or DNA circuit, in 2006. They then constructed a 5-layer 12-DNA molecule circuit from these gates – and the processing speed fell off a cliff, orders of magnitude slower. Back to the computer modeler, as they say. The result is a new design, published in the June 3, 2011 issue of Science and available in a version without paywall at Royal Society Publishing 6 June 2011, [A simple DNA gate motif for synthesizing large-scale circuits] One of the circuits built with the new approach used 74 different DNA molecules, the largest such circuit to-date, which can calculate the square root of numbers up to 15. Yes, obviously this is not even a crude silicon calculator, but that comparison misses the point entirely. More »

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Finally, a self-powered wireless nanoscale sensor

nanogenerator
Nanogenerator system……….Credit: NanoLetters, American Chemical Society

One day the world may well be blanketed with sensors (metaphorically). If so, it will be the result of advances in nanotechnology. Perhaps it will be derived from the work of Zhong Lin Wang and his group of ambitious researchers at The Georgia Institute of Technology (Georgia Tech, Atlanta, USA).

Publishing in the American Chemical Society (ACS) journal NanoLetters 23 May 2011, Paywall [Self-Powered System with Wireless Data Transmission] Zhong Wang addresses overcoming two of the biggest hurdles in the development of ultra-small (near nanoscale) sensors: energy source and data collection.

The point of sensors is that they capture information – measurements, images, sounds, motions, chemical presence and so forth. However without the ability to collect and analyze that information (data) sensors would be pointless. Historically most sensors have been wired into a network, for example the sensors in a car, or they broadcast the data as in many RFID (Radio Frequency Identification) approaches. Historically most sensors have been ‘human scale’ meaning big enough to be seen by the human eye and manipulated with the human hand. Not so, of course, for sensors built with nanotechnology.

At this scale are sensors not only invisible to the human eye, they require very powerful microscopes to be seen at all. Likewise at this scale an implementation of a sensor network doesn’t (usually) mean a few sensors, it means thousands (or even millions) of sensors. Data collection at the nanoscale is a problem. More »

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Better communications: One laser – 26 Terabits per second, a new record

Imagine transmitting the content of the entire Library of Congress in ten seconds. Yes, that’s fast. That communication speed translates to 26 terabits per second, which is, for now, the fastest speed attained by a communication system using a single laser beam and optical fiber.

Actually not so long ago people could barely imagine transmitting the Library of Congress in one go, in fact, the question might have been why would anyone want to? This does sound like a dumb question, or at least the kind of question you’d expect from somebody who has never used a computer on the Internet. However, another way to think about it – what would you do with the content of the Library of Congress if it arrived in your computer in ten seconds? (You’d better have a rather large rack of disk storage, for one thing.) So, okay for an individual this kind of speed isn’t relevant. Where it is relevant, of course, is in the ‘backbones’ (main transmission lines) of the Internet where millions of individual communications are happening every second, and where the sharp rise in video-on-demand is loading more data onto lines than ever before. In that context 26 terabits per second is good, not great but good.

Why not great? Let’s start with a couple of factoids to tuck into your memory cells: A terabit is 1,000,000,000,000 bits. That’s twelve zeros to the one. It makes for a large looking number. The other factoid is a phrase: orthogonal frequency division multiplexing, a technique that uses multiple lasers to create data streams in different colors and shoot them down the line together. This approach has reached 100 terabits per second. The problem is it takes 370 lasers, which are not cheap – nor is the energy requirement.

What the researchers at Kalrsruhe Institute of Technology (KIT), Germany have done is achieve the 26 terabit speed with one laser. Nature Photonics [22 May 2011, paywalled, 26 Tbit s?1 line-rate super-channel transmission utilizing all-optical fast Fourier transform processing] More »

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Protein complexity could be our demise

Did you know that badly folded proteins could be the cause of our species’ destruction? Neither did I.

I know about nuclear bombs, climate change, asteroid strike and even pandemic as possible doomsday scenarios. I’m aware of predictions that in the not too distant future mankind might be overpowered by or merge with artificial intelligence (the Singularity). I know of plenty science fiction tales of ‘gray goo’ or some other nanotechnology disaster. In fact, to be honest, I’m becoming somewhat inured to the various ideas of how human beings could cease to exist. “Yeah, yeah…tell me about it next week.”

So when a couple of major science publications run a relatively brief article, Nature News 11-May-2011, paywall [The Achilles’ heel of biological complexity] and Scientific American 12 May 2011, paywall [Why Are You So Complex? Complicated Protein Interactions Evolved to Stave Off Mutations] which states:

…it may be a losing battle. Genetic drift may eat away at the ability of our proteins until they are overwhelmed, leaving us a sickly species.

“Species with low population are ultimately doomed by nature’s strategy of evolving complexity.”

I don’t get all that stressed. Neither does the article. Yet…the story is interesting in how it casts light upon a little discussed aspect of biology, the behavior of our proteins (and the field of proteomics), and their importance to life. More »

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Posted in Impact: Proteomics | Tagged , , , , , , , , , , | 1 Comment

Synthetic biology: Improve photosynthesis

Eighteen blue-ribbon scientists from all over the world agree: We need to improve on Mother Nature. Oh? Well, yes. Nature only extracts energy from the Sun in a couple of band gaps (otherwise known as colors), mostly green, some blue. We can do better than that. We can engineer plants to absorb photons from the Sun in lots of band gaps such as the reds, and purples, and even infra-red. That way, instead of letting all the good color wavelengths go to waste, we can have plant stock capturing far more energy.

The description above is a gross oversimplification, of course, but in essence this is what a joint paper published in the journal Science [03 May 2011, paywalled, Comparing Photosynthetic and Photovoltaic Efficiencies and Recognizing the Potential for Improvement] is saying. The target for this improvement on nature is biofuels.

The study itself compares the efficiencies of solar photovoltaic devices (solar panels, etc.) compared to photosynthesis and finds photosynthesis lacking. For evolutionary reasons, most photosynthesis occurs with the green and some blue portions of the spectrum. This is sufficient for the needs of plants and algae. It is not, however, good enough for human energy needs. More »

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Arctic Council: Getting serious about making money from global warming

Oh the irony. On the one hand there is the well propagandized denial of global warming, which is so effective in some countries (the United States chief among several) that politicians of all (yellow) stripes dare not mention its name. On the other hand there is this:

Secret US embassy cables released by Wikileaks show nations are racing to “carve up” Arctic resources – oil, gas and even rubies – as the ice retreats. They suggest that Arctic states, including the US and Russia, are all pushing to stake a claim. The opportunity to exploit resources has come because of a dramatic fall in the amount of ice in the Arctic. The US Geological Survey estimates oil reserves off Greenland are as big as those in the North Sea.

The cables were released by the Wikileaks whistleblower website as foreign ministers from the eight Arctic Council member states – Russia, the United States, Canada, Denmark, Norway, Finland, Sweden and Iceland – met in Nuuk, Greenland on Thursday to sign a treaty on international search-and-rescue in the Arctic and discuss the region’s future challenges.

[Source: BBC Newsnight]

The Arctic Council, a talkathon operation for most of its history, suddenly becomes the center of attention as eight nations scramble in what might be called unseemly fashion to place dibs on the treasures being revealed as the arctic icepack disappears as a result of global warming.

Now who you gonna believe, the warming climate deniers or the governments and corporations racing to plant flags and claims all over the arctic? More »

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World population estimate for 2100 revised – up

Ask around about the ‘overpopulation issue.’ The reply is likely to be: What overpopulation issue? For anyone cognitively aware before 1990, that was one of the biggest issues of the era, right up there with the means of reducing the surplus population, which was called global thermonuclear war. For recent generations, it is hardly a topic of discussion. That does not mean the issue has gone away.

As a reminder, consider that the United Nations has just issued an update to its estimates of world population, World Population Prospects: The 2010 Revision covered in a United Nations Press Release [03 May 2011, World Population to reach 10 billion by 2100 if Fertility in all Countries Converges to Replacement Level]. The estimate of world population for 2100 has – shock – been revised upward from approximately 9 billion to 10.1 billion. Perhaps even more thought provoking is the estimate that there will be 9 billion by 2050.

In October of this year (2011) the world population is expected to pass 7 billion, having achieved that from 6 billion in just twelve years. From some perspectives, it looks like humankind did that without breaking a sweat. And the next billion? And the next, and the next? History is an unreliable teacher, since in the 1980’s it looked like overpopulation was well on the way to destroying civilization as we knew it by 1995 or so. Then came the green revolution and the beginning of population stability or decline in many of the major developed countries. The disaster didn’t happen, which of course meant that many people began to assume it couldn’t happen – technology would always come to the rescue. More »

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New solar heat technology: Make electricity and hot water

Solar panels that directly capture energy from the sun and convert it into electrical energy are well known and recognized as a major source of alternative energy. Solar panels that make hot water are popular in some parts of the world (China, Europe, Brazil, India) and the technology is well known. Solar panels that use the sun’s energy to create heat and then turn it into electricity and hot water are not so well known. That’s because as a practical matter, the approach is new. Most electricity generated by solar heat is produced at installations with specially focused mirrors that track the movement of the sun – which is obviously expensive. The new approach, developed by a team from the Massachusetts Institute of Technology (USA), Boston College (USA) and GMZ Energy (an MIT, BC spinoff company) and published in the journal Nature Materials [1 May 2011, paywalled, High-performance flat-panel solar thermoelectric generators with high thermal concentration] uses a flat panel system looking very much like traditional solar panels. Traditional, however, it is not. More »

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Graphene transistor: Two layers may be better than one

One of the characteristics of clever science is to look at a new material from every which way. So it is with graphene. Graphene is a sheet of carbon atoms, in a layer one atom thick, arranged in the pattern of a honeycomb. It sounds simple, and is anything but. Its super-thinness in this precise configuration gives graphene amazing electrical and quantum mechanical properties – as well as being one of the strongest materials known. Scientists invent a new application for graphene just about every month. One of the most persistent applications is to make a semi-conductor out of it; it seems like graphene ought to make transistors and other electronic components, just like or even better than those made of silicon. But there’s a catch: Graphene doesn’t have a band gap.

Put simply, the band gap is a space between the layer of electrons bound to an atom’s nucleus, the valence layer, and a layer of electrons that are free to move about from atom to atom, the conduction layer. In many metals these two bands are on top of each other and electrons flow freely between them and between atoms – which makes metals a good conductor of electricity. In other materials, there is a large gap between the valence and conductive layers, which electrons cannot cross – making such material an insulator. Finally there are materials with a small band gap that given enough of a kick, the electrons can jump between the bands – these are called semiconductors. Most of modern electronics are built upon the band gap properties of semiconductor materials, principally silicon. Without a band gap, graphene doesn’t make a semiconductor, although there are many avenues of research to get around this deficiency.

While it’s true that a layer of graphene has no bandgap, it occurred to scientists at the National Institute of Standards (NIST, USA) that having two layers of graphene might have a space between them that could act like a band gap. As described in the journal Nature Physics [24 April 2011, paywalled, Microscopic polarization in bilayer graphene] two layers of graphene (a bilayer) placed on a third non-conducting layer (a substrate) produces bandgap-like effects. However… More »

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Laser sparkplugs: off the drawing board

In the never ending search to squeeze energy savings out of old technology, in this case the internal combustion engine, researchers working with Takunori Taira at the Japanese National Institute of Natural Sciences have developed what appears to be a production capable laser sparkplug. Let’s unpack the last four words: Sparkplug – those are the ceramic gizmos in vehicle engines that ignite the fuel (the ‘internal combustion’); they’re critical to the timing of the engine and the efficiency of burning the fuel. Laser sparkplug – conventional sparkplugs make their spark with electricity, a sudden flash that ignites the fuel; a laser sparkplug uses the heat of focused laser light to make the ignition. Production capable – laser sparkplugs are not a new idea, but the difficulty has always been making a version that is reliable, durable, and inexpensive. More »

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New technology: An optical microscope without lenses

Say ‘microscope’ and most people think of the models they had in school. Those microscopes had lenses and used visible light (either natural light or a bulb of some kind). Generically they’re called optical microscopes. So what’s a microscope called if it doesn’t have any lenses? Try lens-free optical tomographic microscope. And this means what?

Biological samples, especially if they’re living, are difficult to put under a microscope. Microscopes based on visible light are relatively friendly to biological samples, but the wavelength of visible light is pretty big so that there are limits to the resolution of a typical optical microscope. Sure, new technologies such as the Atomic Force Microscope (AFM) or the Scanning Tunneling Microscope (STM) use electrons and other high-energy particles to work at very high resolution – atomic scale. They also ‘fry’ most biological samples. Living samples don’t stay that way for very long.

So scientists have worked for many decades to improve the optical microscope, and the lens-free optical tomographic microscope is one of the results. More »

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Harm from video game violence: Weighing the pedigree of the evidence

There are many issues in the modern world for which arguments can be made on both sides (assuming a two sided issue). Courts deal with some of these issues and judges too must find a way to wade through enormous stacks of studies and briefs for one side and the other. (Legal systems generally take two sides, prosecution/defense, as a baseline.) One of these issues is whether violence in entertainment (movies, games) has negative real-world impact. For example: Does video game violence harm teens? One side says yes, it does, and proceeds to present many studies indicating that various levels of violence and youth involvement in video games lead to violent attitudes and acts. The other side presents similar studies indicating that no such effect exists, or if it does it is statistically insignificant. There is so much information and conflicting opinion on this issue, that it is extremely difficult to pick apart the arguments at the level of evidence and tease out “the truth.” In short, judges despair.

Now here’s an interesting approach to this kind of problem: Weighing the credibility of the providers of the evidence.

Three psychologists, Brad Bushman at Ohio University, Craig Anderson at Iowa State University, and Deana Pollard Sacks at Texas Southern University (all USA) considered a specific instance of the scientific evidence for a case before the United States Supreme Court. [To be published in May, 2011 in Colloquy: Northwestern University Law Review] The case, Schwarzenegger v. Entertainment Merchants Association, will decide whether the state of California (Schwarzenegger was governor when the case was filed) can ban the sale or rental to children under 18 of video games containing excessive violence. The case involves Big Money, Morality, Religion, Parental Rights, Freedom of Expression, and Children’s Rights, among other things – or, in short, this is the kind of case supreme courts are loath to handle. For one thing, there is the vast amount of evidence: in this case 197 people are presenting material (amicus curiae – advice from ‘friends of the court’). The stacks of material – not counting referenced sources – run to many feet for each side. Of course the court’s law clerks do most of the reading, but still, how are judges supposed to weigh the testimony of experts when they are not experts themselves? It’s a common problem, not only for the law, and the researchers present one way of dealing with it. More »

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Graphene gets spintronics

The basis of microelectronics is the manipulation of charged electrons. The basis of spintronics is the conversion of electricity to magnetism and vice versa in order to manipulate the spin of electrons. Both approaches can produce transistors and other elements used in electronics (computers et al), but spintronics has advantages: Unlike the charge of electrons, the spin of electrons does not require a continuous electrical current. In other words, the spin is retained when the power is off. As a corollary, setting the spin of electrons requires only a short burst of energy (magnetic) to set the spin, which means spintronic devices require less power than conventional semiconductor devices. Also, spintronic devices don’t require semiconductor materials and can be made from common materials such as copper, aluminum – and now graphene.

Graphene is carbon (how very common) that has many unexpected electrical properties due to its form (one carbon atom thick sheets) and atomic configuration (the carbon atoms are arranged in a hexagonal “honeycomb” pattern). Since it was first popularized and exploited by Andre Geim and Konstantin Novoselov, who received the 2010 Nobel Prize in Physics for their work, graphene has revealed one amazing capability after another. This time Geim and Novoselov are back to demonstrate the ability of graphene to magnetize in a way useful for spintronics. More »

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No WIMPS in the Xenon

It is a strange headline – No WIMPS in the Xenon, but then Dark Matter is strange. It supposedly must exist, in fact, it makes up 25% of the material in the universe. However, it has never been seen. Not seen even by the latest super high sensitivity detector project called XENON100. Located at the Gran Sasso National Laboratory in Italy, XENON100 is looking for the signature of dark matter – a WIMP, a Weakly Interacting Massive Particle. Put another way, Dark Matter is supposed to be a (relatively) massive elementary particle, which (unfortunately for science) doesn’t interact much (or at all) with normal everyday matter. That makes it (very) difficult to detect. In fact, this latest and most sensitive test by XENON100 has not detected any WIMPs in a year’s testing.

However the motivation to detect a WIMP is great. If the existence of dark matter can be demonstrated by finding WIMPs, then an array of models and theories in physics, related to what is referred to as the supersymmetry model (SUSY) become at least partially validated. What’s at stake (besides a lot of jobs and reputations in theoretical physics) is the ability to fill in gaps of explanation for the way in which the cosmos (universe) formed, and further explanation for the behavior of fundamental particles at the sub-atomic scale. More »

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Stem cell research: Synthetic retina tissue

This is a ‘Don’t jump to conclusions story.’ Scientists working with the RIKEN Center for Developmental Biology (Kobe, Japan) and published in the journal Nature, 6 April 2011, Paywall [Self-organizing optic-cup morphogenesis in three-dimensional culture] have announced that mouse embryonic stem cells have been induced to grow a retina-like structure. Let’s parse that last statement: The embryonic stem cells come from mice, meaning that from mice to man will be a long transition, at best. What was induced to grow (using techniques of synthetic biology) was retina-like, meaning that the formation resembled the light sensitive organ of eyes (the retina) in both cellular structure and shape (cup like). The ‘like’ part has to be added because the researchers did not test whether these cells were actually sensitive to light (photosensitive) or could be hooked up to other visual neurons. So what they did is create a very interesting tissue culture, pointing in the direction of growing replacement elements for eyes. More »

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Breast cancer study: 50 women, 1700 genetic mutations

It isn’t always true for science, but it sure seems like the more we learn, the more complicated the knowledge becomes. Take breast cancer for an example. Every few months a new study is published that announces the discovery that this that or another gene is ‘linked to breast cancer.’ Likewise there is a stream of news about studies finding correlations between various environmental influences – food, smoking, alcohol, pollution, and lifestyle – also related to breast cancer. Typically these studies conclude by saying something like, ‘although this study is preliminary, the linkage between “x” and breast cancer may lead to new treatments and a potential cure.’

Given that there are millions of women (and a few men) for whom such hope is paramount, each one of the announcements may be greeted with enthusiasm. Even if each of these discoveries doesn’t turn out to be ‘the cure,’ surely collectively they must indicate progress toward finding a cure? Well, yes they do, but the question has to be, how much progress?

That gets me back to the original problem of knowing more. A team of scientists at Washington University (St. Louis, Missouri USA) led by Matthew Ellis performed a feat of massive computational proportions by sequencing the whole genomes of 50 women with breast cancer. The resulting paper, to be published in Nature magazine was previewed as a news article. [ Fifty genome sequences reveal breast cancer's complexity] The research entailed sequencing 50 genomes from the tumor cells, and 50 genomes from healthy cells and then comparing them, looking for alterations in the genome. They found mutations, lots of them. More »

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NEWS: Short List

Restraining and studying molecules, two at a time – Photonics | The usual way of studying how molecules react to a catalyst is to put them into a solution and observe – typically huge numbers of reactions. This works to a point, the point being the amount of detail that can be surmised from so many individual reactions. Now instead of observing a whole mess of molecules, what if you could observe precisely two molecules react? This level of resolution might lead to new insights, but how do you get to observe just two molecules? That’s what the technique devised by a team of UCLA (University of California Los Angeles, USA) researchers does – it ‘restrains’ exactly two molecules of photosensitive material (materials used in solar cells in this case) using a shape-fitting form of nanoparticles. The nanoparticles assemble on a surface (substrate) of gold so that there are shapes (defects) that precisely fit the shape of the target molecules. These molecules are ‘stuck’ to the shapes so they can be observed with a scanning tunneling microscope while they are activated with ultraviolet light. The technique is called regioselectivity, regio being the catalyst (or reagent) and the selectivity is the way in which the molecules align. In this case, the researchers are attempting to find better alignment for critical molecular components in solar cells with the hope of increasing the efficiency.

[Science Magazine 11 March 2011, Creating Favorable Geometries for Directing Organic Photoreactions in Alkanethiolate Monolayers]

Nanoballoons for cancer therapy – Nanomedicine | There are many ways researchers are looking into using nanostructures (such as nanotubes, nanowires, nanoparticles) to deliver medicine to very specific targets (often cancerous tissue). One of the more promising was developed by a research team at Princess Margaret Hospital (Ontario, Canada) that uses what might be called nanoballoons, structures no bigger than 1/100,000 the width of a human hair that look like a colorful balloon. The nanoballoon is created by combining chlorophyll and a lipid (fat) and distinguishes itself from other nanoparticle forms in being biochemically safe (non-toxic) and usable in several different techniques: Photothermal therapy to heat cancer cells until they are killed, photoacoustic therapy to find and remove cells, and as a container to hold chemotherapy drugs for precise delivery to a cancerous area. The research has prototyped the nanoballoon techniques but much more work needs to be done to show that this particular approach can be used clinically.

[Nature Materials 20 March 2011, Porphysome nanovesicles generated by porphyrin bilayers for use as multimodal biophotonic contrast agents]

White dwarf stars: A good place to look for Earth-like planets – Exogenous Life | Stars come in many sizes and conditions, although ‘enormous’ and ‘very hot’ sort of cover the lot. However, there are also a number of ‘colored’ star types known collectively as ‘dwarfs’ – red (low mass), yellow (like our Sun), white (a dying star), black (a white dwarf emitting no visible light) and brown (smaller than a star with minimal heat). In general these stars are less energetic (including less explosive and violent), a condition that favors retaining planets in the ‘Goldilocks zone’ – orbits that are close enough to the star to get sufficient heat, but not in danger of being destroyed by emissions from the star. This is the zone Earth occupies and it is presumed that similar earth-like planets might exist. The implication is that such planets could harbor life. A new paper by Eric Agol at the University of Washington (Seattle, USA) suggests that white dwarfs would be a good place to look for these planets. Because white dwarfs are small and relatively cool, planets can exist much closer to the star and that should make them easier to spot with current telescope technology. There are approximately 20,000 white dwarfs relatively close to Earth.

[Astrophysics Journal Letters 5 April 2011, Eurekalert]

A primordial soup revisited – Origin of Life | In 1953 Stanley Miller began a series of experiments designed to explore the idea of a primordial soup, the mixture of chemical ingredients that could lead to the origin of life on Earth. His first research used a simple mixture of water, methane, ammonia and hydrogen – common chemicals in asteroid and meteor bodies – through which was passed an electric current. The results, which were startling at the time, were a number of complex amino acids, the building blocks of life. Miller continued his research through 1958 but he died in 2007 leaving his notes and experiments unfinished. One of Miller’s former students, Jeffrey Bada has picked up the research, using tools and instruments more sophisticated than those available to Miller. In one new experiment, based on Miller’s notes, hydrogen sulphide (the smell of rotten eggs) was added to the mix. The results included an astonishing 23 amino acids, four amines and seven organo-sulphur compounds. Keep in mind these are pre-biotic materials that are considered necessary for organic life but have not yet been combined in a way to actually create life. What that process was, as yet, is unknown. Nevertheless, the results indicate that from some very common chemical substances and a simple electrical discharge the basic organic components of life can be made. This knowledge increases the probability that life could have formed many places in the universe.

[PNAS 21 March 2011, Primordial synthesis of amines and amino acids in a 1958 Miller H2S-rich spark discharge experiment]

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Orbiting Mercury: The message of Messenger

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Messenger orbital trajectory…..Credit: NASA

For the first time in perhaps two billion years the planet Mercury has a satellite. This moonless planet, which is itself smaller than many moons in the solar system and whose surface looks very much like Earth’s Moon, now has a tiny metallic canister in orbit around it, the Messenger space probe. Human science, engineering and money put it there, and it wasn’t easy. It’s a pity the achievement will be underappreciated.

Launch a rocket in Florida (USA) in 2004; lofting it through Earth’s atmosphere and send it on a trajectory consisting of a dozen enormous concentric orbits around the Sun covering 9.9 billion kilometers (6.2 billion miles) over 6 ½ years. Along the way fly by the Earth, Venus (twice), Mercury (three times), all the while chasing the orbit of Mercury and trying to use the planets and Sun to brake the Messenger spacecraft so that after a final burn of its main engines, it slips neatly into a complex elliptical (egg shaped) orbit around Mercury – close enough at one point to take good pictures (about 200 km/124 mi) but also far enough out (15,160 km/9,420 mi) at the other point to cool off.

All this Messenger completed March 17, 2011, and did it perfectly.

I think the achievement deserves a little ‘Huzzah!’ Not all space probes reach their destination and few had as lengthy a journey or were even remotely as complicated in trajectory. Oh, and of course, all the instruments, computers, and communications must work when it gets there.

Price tag: $446 million. Fortunately Messenger launched while the United States still had a taste for science and NASA still had a workable budget. More »

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Fuel cell technology: Fuel from an ‘artificial leaf’

Visions of catchy titles danced in my head: “Alternative energy turns over a new leaf,” for example. It sounds like a perfect story for a world growing ever more skittish about the future of energy. (As Fukushima continues to radiate danger and fuel prices head into economy busting territory.) The idea is to produce energy using a device that mimics the photosynthetic abilities of nature – an artificial leaf.

The “leaf” in this case is a silicon-based square about the size of a large business card. Drop it into water with plenty of direct sunlight and its catalytic properties split the molecules of water (H20) into hydrogen and oxygen gas. Anyone who follows alternative energy will immediately recognize what this means – fuel cell. The hydrogen gas is the primary source of energy for fuel cells, one of the big hopes for the future of clean “green” energy.

Unfortunately, color me skeptical, not green.

There are labs all over the world working on various forms of artificial photosynthesis. This particular artificial leaf idea comes with good pedigree from the lab of Daniel Nocera at the Massachusetts Institute of Technology (USA). He got the idea from researchers at the U.S. National Renewable Energy Laboratory (Boulder, Colorado), who developed a similar device in 1998 but used platinum, or other similarly expensive materials for catalysts and which did not last a day. The achievement for the MIT lab was to use much less expensive materials, nickel and cobalt, to operate continuously and at a high level of output for around 45 hours. The key is that this ‘artificial leaf’ produces gasses that can be stored and used in a fuel cell system – there is no need for electrical storage such as a battery. More »

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Updated scientific comparisons

One evening a gaggle of white-smocked scientists started throwing comparative pejoratives at one another, something like this:

- He’s as bored as a geologist on the open sea.
- Smart as a monkey with a mass spectrometer.
- He doesn’t know a cetacean from a cephalopod.
- That’s as much fun as a fragile rectal thermometer.
- They were as claustrophobic as astronauts in a cave.
- He was as happy as a geneticist in a bucket of histones.
- He couldn’t tell a quantum effect from an elephant fart.
- She was as nervous as a psychologist at a psychiatric convention.
- That’s as easy as finding a Higgs boson.
- She was as cute as pi.
- They were just like two P’s in a phosphorus chain.
- He was shaking like a chemist with a bag of acetone peroxide.
- He was as helpless as a mathematician wearing mittens.
- She was lost like a cartographer in a cavern.
- Happy as a horticulturist in a seed bag.
- As disgusted as an astronomer in an astrology shop.
- About as logical as a computer scientist on LSD.
- It was as palpable as dark matter.
- Frowning like a bishop with a mouthful of stem cells.
- As trustworthy as a meteorologist on vacation.

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Connecting to neurons with semiconductor nanotubes

“Patching into the brain” is a staple of science fiction and you hear about it fairly often in neuroscience; connecting ‘wires’ into the brain somehow seems routine. It’s not. Scientists and sometimes doctors do lots of things with reading or probing the brain with external (on the skin) sensors. They also occasionally do neural implants of one kind or another, usually electrical stimulus or probe devices placed strategically in a brain location. Any time the brain is approached with an invasive technology (makes actual physical contact with brain tissue); it’s a tricky and often dangerous business. Most of the research is done with animals.

What is not yet available is a reliable, non-destructive, relatively safe way to connect with the elements, for example axons, of specific neurons. As an example of a new approach to connecting neurons and as an example of a new use of nanotechnology, researchers at the University of Wisconsin (Madison, USA) led by Justin Williams found that by seeding areas outside of variously shaped nanotubes (in this case extremely fine tubes of layered silicon and germanium) with mouse neurons, the neurons produced axons (filaments) that would readily enter and grow through the tubes. The results published in ACS Nano, 2 March 2011, [Semiconductor Nanomembrane Tubes: Three-Dimensional Confinement for Controlled Neurite Outgrowth] represent the kind of ‘could-be really important’ research, very early in its development, or it could be very little at all. More »

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The scale of radiation dosage

radiation dosage
The impact of radiation dosage – scaled…………………Credit: xkcd.com (public domain)

In case you haven’t seen this somewhere else:

The brilliant (if obscurely warped) mind of xkcd has strayed from the comic realm into the realm of information display – with remarkable results.

Go to the source, check it out, enlarge the original, print: Paste it to the physics/biology/chemistry lab door.

Radiation chart at xkcd.com

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NEWS: Short List

Targeting cancer with magnetic microcarrier – Nanomedicine | As a rule chemotherapy is like using a blunderbuss against cancer. ‘Chemo’ is administered through the bloodstream, which of course goes everywhere in the body. While the anti-cancer chemistry can be targeted to a certain extent, it almost always has toxic side effects with other organs and systems. Consequently, one of the most important goals of cancer research has been improvement of targeting – getting just the right chemistry to just the right location (specific cells). There are many avenues of research, one of the most promising uses nanotechnology. Recently Sylvain Martel and colleagues at Polytechnique Montreal (Canada) used a specially rigged MRI system to guide a tiny sphere, dubbed a microcarrier, magnetized with nanoparticles. Inserted into the hepatic artery of a rabbit, the sphere was magnetically moved into position within a specific area of the liver where its contents (doxorubicin) were progressively released. This technique appears ready for preparation to be used in human trials.

[BioMaterials, Volume 32, Issue 13, May 2011, Pages 3481-3486, Co-encapsulation of magnetic nanoparticles and doxorubicin into biodegradable microcarriers for deep tissue targeting by vascular MRI navigation]

W.H.O. response to pandemic that wasn’t is criticized – Pandemics | The H1N1 “Swine Flu” pandemic of 2009 fizzled. Thank goodness. The World Health Organization (W.H.O.) received a lot of criticism for promoting a worldwide pandemic management and vaccination program, in large part because the H1N1 virus (a cross of pig, human and avian genetics) turned out to be no more virulent than ‘normal’ flu. Now a follow-up study of the H1N1 episode, at the behest of W.H.O., finds that the world was lucky: W.H.O. and its member countries, particularly those involved with the new International Health Regulations (IHR) were not and are not ready for a seriously dangerous pandemic. The report, which will be officially released later this year, largely clears W.H.O. for its timing in declaring an emergency and for charges of being influenced by large drug companies, but it finds fault with the uncertainty of W.H.O. categorization of the outbreak and with the ability of W.H.O. to manage the IHR agreements between countries. Consider the 2009 H1N1 outbreak a dry-run, a chance to critique and improve the world’s response capability. The next outbreak may not be so meek.

[New York Times, 10 March 2011, Response of W.H.O. to swine flu is criticized]

Title – Photonics | Perhaps you’ve heard that quantum computers are ‘just around the bend’ so to speak. It could be a long curve. Nevertheless, by the time quantum computers become real it would be a good idea to hook them to quantum networks. To that end researchers at Northwestern University (Illinois, USA) have demonstrated a network switching device (a switch changes the route of network information) that can handle quantum bits (particles of light involved in the quantum effect called entanglement) without losing the embedded information. In this case the quantum bit (qubit) is a photon, which is emitted by a device the researchers created called a Entangled Photon Source. Pairs of entangled photons (entangled meaning that both photons are linked by a quantum relationship) are transmitted via optic fiber through the new photonic switch – without losing their entanglement. This quantum communication is many times faster than existing digital systems and only needs quantum computers to become the high powered computing of the future – a few years down the line.

[Physical Review Letters, 1 February 2011, Ultrafast switching of photonic entanglement]

Synthetic biology: Replacement urinary tubes – Synthetic Biology | The first human replacement of damaged urinary tubes (urethra) with synthetically produced tissue may not seem like a glamorous piece of synthetic biology, and it isn’t – and that’s the point. Researchers are now developing ‘artificial’ tissue replacements for a number of organs, many of them sort of ‘routine’ but nonetheless vital for the person whose native equipment is defective. The researchers at Wake Forest Baptist Medical Center (USA) have progressed to human trials, in this case, replacing long segments of urinary tubes in five boys. Creating these tubes with tissue grafts has a high failure rate (around 50%). The synthetic tubes are grown from the patient’s own cells and do not provoke a tissue rejection. They are more easily controlled for size, shape and consistency, which should result in a much lower failure rate. Determining that rate will be part of the next phase of human testing.

[Lancet, 8 March 2011 Tissue-engineered autologous urethras for patients who need reconstruction: an observational study]

Nanotiles make a programmable processor – Computer Power | Using nanotechnology components for computing is one of the most active of all research areas. Much of the activity concerns using nanotubes and other carbon-based nano-shapes for digital switches (for memory and logic components). In this case engineers and scientists at Harvard University and MITRE Corporation (USA) have created nanowire tiles that can be arranged in the world’s first programmable nanoprocessor. Charles Lieber and colleagues use carbon nanowires that are arranged by some breakthrough processing technology to form circuitry on a ‘tile’ (a substrate material). This is analogous to printing circuits on silicon chips of traditional computing, but here the tiles are at the nano scale. They are so tiny that the power consumption is negligible and each circuit can retain a charge (like computer memory), yet stacked together the tiles form complex circuits that can perform logic and arithmetic. This combination of non-volatile memory and programmable circuits – at the nanoscale – constitutes a new and potentially important approach to developing computers ‘from the bottom up.’ That is, instead of designing complete circuits and imprinting them on a semiconductor, the processors circuits are built piece by piece (tile by tile). The end product will be, in the not too distant future, computer processors no bigger than the head of a pin (on which the angels will dance).

[Nature, 9 February 2011, Programmable nanowire circuits for processors]

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Fukushima Meltdown

As I write this, daylight has overtaken Japan on Tuesday morning, there has been a third explosion at the Fukushima Daiichi nuclear plant; this time in the second reactor. It appears that some kind of core containment breach has occurred, which will mean at minimum more released radioactivity. The staff has been evacuated, at least temporarily. There is an increasing danger of a core meltdown, which increases the risk of a steam explosion with far more radiation dispersal. The voice of the Japanese Prime Minister is wan and tight as he announces an increasing level of radiation emanating from the plant. I get the sense that the situation is all but officially out of control. Japan waits and in fact the whole world waits to see what happens next.

Whether Fukushima actually has a core meltdown (possibly more than one) or not, this is still a meltdown. As an alternative energy source to fossil fuels, nuclear power will have difficulty recovering. In a way nuclear energy suffers from the same problem the as airlines. The airline industry flies thousands of planes, billions of kilometers, and millions of passengers – day after day – with only a very few planes in any one year suffering a catastrophic accident. Yet almost each and every accident is accompanied by dramatic media coverage, and we are reminded yet again how dangerous it is to fly. When, of course, it isn’t.

Nuclear power plants have a similar problem, only a bigger problem by orders of magnitude. There are over 400 plants in operation around the world, and this is the third major event in over half a century. By the numbers, the ratio of accidents to days of normal operation is very low. It doesn’t matter. When there is an accident, it scares the shit out of us. It goes into the history books and into our language along with names known around the world: Three Mile Island, Chernobyl.

In this case Fukushima stands in direct comparison to the damage done by the forces of nature that caused the nuclear emergency in the first place. No matter how bad it becomes, Fukushima won’t even come close to the effect of the 9.0 earthquake and following tsunami: Thousands and thousands of dead, whole cities destroyed, a great industrial nation brought to a commercial stand-still. Yes, but that was Nature. We can do nothing about earthquakes. Fukushima was made by humans – by us – by and for us. Therefore, we sense this is a very different situation. We have responsibility.

Of course, no country has a greater appreciation – horror – of nuclear energy than Japan. Yet as a geographically small island country not blessed with large hydrocarbon resources, Japan elected to develop nuclear energy. It was either that or find its economy unable to keep up with the rest of the world. Of course, the Japanese knew they were building nuclear power plants on the “Ring of Fire,” the seismic and volcanic edge of the Pacific Ocean. They took the risks. The insurers took the risks.

Today those risks don’t look so good. They look worse to those who consider insuring nuclear power plants. They look worse yet to the many people who consider nuclear energy not only an unacceptable risk, but an abomination.

So the impact of Fukushima, the magnitude of disaster which is still unfolding, will be like that of Chernobyl and Three Mile Island. Yet again those who want to take the risks for the sake of prosperity and comfort must also face the potential costs and losses – along with millions of other people who have little or no say in taking those risks. The political ripples will be mighty and unavoidable.

Once again, the costs of nuclear energy will rise: The technology must not only improve but also new installations must meet much higher standards, making them far more expensive. The insurance costs will go even higher. Where does that put nuclear energy in the spectrum of alternative energies? It is said that ‘peak oil’ is coming (soon, or is already here), which implies we must find alternative sources of energy. It is also often said that all the other alternative energy sources, solar, wind, geothermal, wave power, just can’t scale to provide enough energy. Is this true? The question will no doubt be revisited, yet again.

Unfortunately the costs and losses from other sources of energy are more subtle than a nuclear meltdown, which makes rational calculations very difficult, if not impossible. We’ve been to this point before, and nuclear energy went into a decades-long dormancy. It was just being revived.

A fire has just broken out at the Fukushima Daiichi plant, one headline I see is NUCLEAR CRISIS.

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