Tag Archives: cancer

Cutting cancer cell immortality short

One of the characteristics of cancer cells is that they don’t die of old age. In a sense, they’re immortal – though of course they can be killed. The main reason for their longevity has been traced to telomeres a strip of non-coding genes at the ends of chromosomes. When normal cells replicate very often [...]
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Giving Roger Ebert a voice

The Pulitzer prize-winning movie critic, Roger Ebert, lost his voice to cancer several years ago. He is one among many thousands of people a year who lose their ability to speak from disease or injury. There are some technology fixes for replacing the physical reproduction capability. (See SciTechStory: Replacing the larynx with a palatometer) However, [...]
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Personalized monitoring of cancer recovery

Step by step the treatment of cancer becomes more personalized. The latest advance, in research from John’s Hopkins University (Baltimore, USA), uses a full-genome DNA sequence of a patient’s cancer to determine its ‘signature.’ Thereafter, in screens of blood tests, that signature – usually consisting of the more obvious chunks of rearranged DNA rather than [...]
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Two new cancer-killing nanoparticles

To use an overworked phrase, it’s a paradigm shift: Cancer research is learning how to ‘think small’ with the potential of nanotechnology – nanoparticles specifically. It’s a shift because medical science has been accustomed to cancer-fighting techniques on the level of bringing cannons to kill a fly. Where doctors once treated cancer with a body-wide [...]
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Nanoparticles identify metastasized cancer cells

One of the more common techniques evolving from the use of nanoparticles to study cell biology is the ability to ‘tag’ cells with colored (dyed) nanoparticles. In an important application of this technique, researchers at the Georgia Institute of Technology (USA) have been able to tag cancer cells that travel in the blood of mice [...]
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Why do some cancers resist treatment?

Sometimes one of the most important things about research is the questions it provokes. In this case, the question “Why do some cancers resist treatment?” comes out of research that has found a plausible answer. The work involved a standing question in stem cell research – How does the body regulate the two different kinds [...]
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Brain cancer genome sequenced

The cost of sequencing a human genome has come down, way down; and the value of doing it is going up. Here’s a very good example: scientists at the University of California Los Angeles (USA) recently completed the sequencing of the DNA from a type of brain cancer cell line, a glioblastoma known as U87. [...]
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Formerly, one brain cancer…now it’s four

One of the things that makes cancer so difficult to ‘cure’ is that it has so many forms. Perhaps most difficult of all, as scientists are learning, are cancers such as the most common and usually fatal brain cancer glioblastoma multiforme (GBM). As a new study at the University of North Carolina (Chapel Hill, USA) [...]
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Cancer cause found in cell communication

The link between stress and cancer has been known (or supposed) for many years, but specific evidence has been spotty. A new study by researchers at Yale University and reported in Nature magazine, probed the causes of cancer related to two genes (RAS and scribble), and discovered two not so good pieces of news: Cancerous [...]
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Also tracking: Science and tech disappointments

Turning the year to a new decade is bound to produce a wide variety of retrospectives. Lists are always popular. I came across an interesting list the other day at the Scientific American site: 10 Science Letdowns of the New Millennium by Katherine Harmon. The original is presented as a slide show. Why, I’m not [...]
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Throat surgery the robotic way

Think about having your throat slit, ear to ear – even for removal of cancer. Rather not? That’s what doctors at University of Pennsylvania (USA) thought, especially since this kind of highly invasive throat surgery often makes breathing, eating, and speaking difficult for weeks after the operation. Their response: develop a robotic procedure that makes [...]
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Nanosensors testing blood for cancer markers

Testing lab samples of blood is one thing; there’s lots of control achieved by isolating components of the blood before testing. Testing whole blood, unfiltered and with all components in their usual mix, is another thing. The thing is; testing whole blood is what’s required in the real world. Whole blood is complicated by the [...]
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Powerful peptide penetrates cancer cells

All too often cancer treatments are like taking a howitzer to a hunting party. The treatment might get the cancer, but there’s often a lot of collateral damage. That’s why, almost from the beginning of cancer research, the goal has been to find ways of stopping cancer without harming the rest of the body. Not [...]
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First Implant: anti-cancer vaccine device in mice

Although implanting drug administering devices in living animals is not new, a successful implementation for treating cancer is new. A team of scientists at Harvard University (USA) have developed a disk-like implant, which carries targeted cancer antigens.
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Stapling peptides to drug the undruggable

Turning specific genes on and off is something Nature does routinely. Not so for scientists. In particular, a class of proteins that control whether certain genes are activated or not, so called transcription factors, have been considered unreachable. Because of their complex folded configurations, transcription proteins are highly resistant to modification and have been considered [...]
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Study confirms telomere’s role in living longer

Confirmation is a vital part of the scientific process. In this case confirmation involves our knowledge of telomeres. We know that telomeres, the short strip of DNA found at the ends of chromosomes, play a big role in protecting the DNA from gene loss during the many replications within a cell. One of the 2009 [...]
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Nanoparticles for cancer drug delivery

You’re going to see many stories of drug delivery methods using nanotechnology. Some methods are still quite theoretical; others have already reached the testing stage in animals. Note, however, that so far none have been given the green light for human testing, which says something about the nascent status of the nano-medical field. Much of [...]
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Protecting healthy cells during radiation therapy

Treatment of cancer with radiation therapy is very common, but always hazardous because the radiation usually kills healthy cells as well. Here’s one promising approach to reducing the risk…
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Can we stimulate repair of old muscles?

Yes, we probably can stimulate more repair of muscle cells in older people. Berkeley — A study led by researchers at the University of California, Berkeley, has identified critical biochemical pathways linked to the aging of human muscle. By manipulating these pathways, the researchers were able to turn back the clock on old human muscle, [...]
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Hand-held cancer detection device

Trekkers will remember Dr. McCoy carrying a hand-held device which could instantly diagnose (and often treat) diseases. We aren’t there yet, but this development is indicative of where we’re going: University of Toronto researchers have used nanomaterials to develop a microchip sensitive enough to quickly determine the type and severity of a patient’s cancer so that [...]
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