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Tag Archives: DNA
Gene expression and regulation: It’s the location, baby.
Perhaps it is something like the real-estate business. What three things make a difference for selling a house? Location, location and location. Thus it may be for at least some of the crucial genes involved in the development of the human embryo. Specifically, researchers at the European Molecular Biology Laboratory (Heidelberg, Germany) found that the [...]
Posted in News: DNA Decoding Also tagged development, DNA folding, embryo, Fgf8, gene, genome, histones Comments closed
Sci-Fi Movie Review: Prometheus
[Prometheus. Released June 2012. Directed by Ridley Scott, Writers John Spaihts and Damon Lindelof. DVD/Blu-Ray released. As usual, this “post-viewing review” contains many spoilers.] The opening scene of Prometheus, which demands interpretation right out of the reel, is of a humanoid alien imbibing some kind of nanotechnology that transforms him (it?, there seem to be [...]
Posted in Review Also tagged alien progenitor, aliens, evolution, panspermia, sci-fi Comments closed
Overcoming mitochondrial diseases by having three parents
Whenever I hear about mitochondria, I think of midichlorians, “the force” of John Lucas’ Star Wars, the life energy that binds the universe by being part of every living thing, but especially concentrated in Jedi…and Sith. I don’t know if knowledge of mitochondria inspired Lucas, but there are strong parallels to midichlorians. Mitochondria are part [...]
Posted in Impact: Genetic Modification Also tagged DNA mutation, enucleation, genetic modification, IVF, mitochondria, mitochondrial disease, mitochondrial replacement, spindle transfer, surrogate, three parent IVF Leave a comment
Fetal DNA sequencing: Reading ma and pa’s genome
Depending on how successful interpretation of the personal genome becomes, any method that makes the process easier for collecting the DNA is progress. That’s one way of saying that the future of personal genome medicine depends on the research that finds the links between genes and disease, and how easy and inexpensive it is to [...]
Posted in News: DNA Decoding Also tagged fetal genome, genetic interpretation, genome, infant, Kitzman, non-invasive, sequencing, Snyder Leave a comment
Bonobo Genome: Our ever-lovin’ kin get closer
Ulindi, a bonobo to love……..credit: Michael Seres These days the genome sequencing of yet another plant, animal or insect barely raises an eyebrow, even in the scientific community. It’s important work that increasingly powerful technology and declining cost has made routine, which is a good thing. Once in a while though, a new ‘complete genome [...]
Posted in News: DNA Decoding Also tagged bonobo, chimpanzee, genome, human, Prüfer, sequencing, Ulindi 1 Comment
New sequencing technique opens doors for epigenetics
What’s the difference between 5mC and 5hmC? Yes, the “h” but it is much more than that. Both are in biochemistry shorthand, which unless you’re a geneticist or biochemist you’ve probably never heard of and are not likely to remember. So let’s cut to the chase, oversimplified though it may be: As you almost certainly [...]
Posted in News: Epigenetics Also tagged Balasubramanian, Booth, epigenetics, epigenome, genome, methylation 1 Comment
microDNA: A new piece of genetics puzzle
In the beginning the big discovery was the existence of DNA and RNA. Eventually more refined experiments and better equipment revealed that RNA in particular came in many forms and functions, for example, micro RNA (miRNA) for DNA regulation or piwi-interacting RNA (piRNA) for transposon defense. So far there are 25-27 types of RNA. However, [...]
Posted in News: DNA Decoding Also tagged eccDNA, extra-chromosomal, genome, microdeletion, microDNA, RNA, Shibata Leave a comment
Personal genome disease risk analysis: New study finds important limits
As the cost of sequencing a person’s genome has sharply declined, the enthusiasm for using that genomic knowledge to predict susceptibility to gene-based illness has grown. In fact, it’s been one of the most common topics of medicine in the public media for more than a year. This includes intense debates about whether it is [...]
Posted in News: DNA Decoding Also tagged disease prediction, genome, genome sequencing, Johns Hopkins, personal genome, twins study, Vogelstein Leave a comment
Epigenetics in the brain: Evidence of methylation beyond cell division
Methylation is not a gasoline additive process or nor does it have anything to do with amphetamines. I mention this because methylation is proving to be significant. It is something that happens to your DNA and despite not being very well known by the public, research is showing it to be far more important than [...]
Posted in Impact: Epigenetics Also tagged epigenetic regulation, epigenetics, methylation, neuron, neuroscience, Song Leave a comment
DNA nanosensors
Not all sensors are electronic, or at least if you expand the scope of sensor technology, measurement techniques (which is what sensor technology is about) can also be chemical or physical, among other things. In this case, the sensor is built from DNA and it’s called a DNA nanosensor. The idea behind this particular nanosensor [...]
Posted in News: Sensor Technology Also tagged assay, cell programming, nanosensor, protein, RNA, sensor technology, signaling pathway, transcription factor 1 Comment
lincRNA: A recently discovered RNA organizes stem cell differentiation
What makes a scientist’s heart go pitter-patter? Something like this: When the Broad team discovered more than 3,500 unique lincRNAs in the human and mouse genomes in 2009, “the potential was enormous, and we wanted to know what they could be doing.” [Source: Technology Review] Here’s the scenario: A team of researchers at the Broad [...]
Posted in News: Proteomics Also tagged Broad Institute, cell development, genetics, Guttmann, lincRNA, pluripotent, proteomics, RNA, stem cells 1 Comment
Synthetic biology: Making new proteins with E. coli by adding DNA
Sometimes big advances in science happen without much public notice. That’s often because at the time they didn’t look like big advances in science, or just as likely, they were considered marginally workable, so nobody wanted to highlight them. Here’s one such case to consider: Researchers at Yale University (Connecticut, USA) and publishing in the [...]
Posted in Impact: Synthetic Biology Also tagged biochemistry, E. coli, epigenetics, phosphorylation, phosphoserine, protein, synthetic biology, Söll 1 Comment
Epigenetic memory: Another path for genetic inheritance
As we have all been schooled, DNA determines what is inherited. If it isn’t encoded in the genes, it won’t be passed on. Except it is becoming ever more apparent this isn’t completely true. There is another way that characteristics can be passed to the next generations; it’s called epigenetic memory. Or at least it’s [...]
Posted in News: Epigenetics Also tagged Dean, epigenetic memory, FLC, genetics, histones, Howard, inheritance, stress response 1 Comment
Epigenetics and methylation: New DNA bases linked to protein
Adenine, thymine, cytosine and guanine: These are the nucleobases, or just plain bases of DNA that in pairs called nucleotides carry the genetic code of life. There are four of them, right? At least that’s what most everybody learns. Of course, there is another base, uracil, which is found in RNA where it replaces thymine. [...]
Posted in News: Epigenetics Also tagged cytosine, epigenetics, methylation, new bases, nucleotide, RNA, Tet, Zhang Leave a comment
Toward a new DNA: thymine out, chlorouracil in
Scientists have been twiddling with DNA for some time. While DNA may be the blueprint of life, it is not immutable (of course) and that means the hand of man likes to poke around in the mix. One kind of poking has been to see if one of the bases – adenine (A), thymine (T), [...]
Posted in News: Synthetic Biology Also tagged chemical evolution, chlorouracil, nucleic acids, RNA, synthetic biology, thymine, uracil, xenobiology 1 Comment
Human genetics: The mysterious unequal mutation by sex
By the numbers, geneticists thought about mutations like this: There are six billion pieces (nucleotides) of genetic information in the genome. Three billion provided by the mother and three billion from the father. Based on evolutionary studies, previous estimates reckoned about 100-200 mutations would be passed on to each child. It was assumed that because [...]
Posted in News: DNA Decoding Also tagged genetics, genome, heredity, mutation, sequencing 2 Comments
Protein complexity could be our demise
Did you know that badly folded proteins could be the cause of our species’ destruction? Neither did I. I know about nuclear bombs, climate change, asteroid strike and even pandemic as possible doomsday scenarios. I’m aware of predictions that in the not too distant future mankind might be overpowered by or merge with artificial intelligence [...]
Posted in Impact: Proteomics Also tagged Alzheimer’s, folding, gene-pool, genetic drift, genetics, natural selection, pandemic, Parkinson’s, prions, proteins 1 Comment
Breast cancer study: 50 women, 1700 genetic mutations
It isn’t always true for science, but it sure seems like the more we learn, the more complicated the knowledge becomes. Take breast cancer for an example. Every few months a new study is published that announces the discovery that this that or another gene is ‘linked to breast cancer.’ Likewise there is a stream [...]
Posted in Impact: Major Disease Cures Also tagged breast cancer, cancer, cancer study, Ellis, genetic mutation, genome, MAP3K1, personalized therapy, sequencing 2 Comments
Part of what makes us human may be what’s missing
Here’s one of those scientific questions that contains a highly suggestive fact: Why is it that the tiny water flea (Daphnia pulex) has a record 31,000 genes and the human – the infinitely more complex human – has only 23,000 genes? Here’s another similar question: How is it that the human species is so different [...]
Posted in Impact: Epigenetics Also tagged biogenetics, Daphnia, epigenetics, evolution, gene, genetics, genome, junk DNA, Kingsley, missing DNA, penis spines Leave a comment
Paleogenetics: Unlocking the secrets from DNA of long ago
Eighth in a series of posts inspired by ten topics in ‘Insights of the Decade’ from the December 17, 2010 special issue of Science Magazine The topics are: Inflammation, climatology, tricks of light, alien planets, the microbiome, cell reprogramming, Martian water, the DNA time machine, cosmology and epigenetics. The original articles are now behind a [...]
Posted in Impact: Decoding DNA Also tagged dinosaurs, fMRI, Frankenstein, gene sequence, Jurassic Park, Neanderthal, paleobiology, paleogenetics, Splice, STM Leave a comment
Proteins and quantum transition: Instant shape-shifting
Every once in a great while a piece of very interesting science comes along, quietly, until more and more people notice that not only is important but it may be right. Then scientists get into high gear and start doing more intensive experimenting. Sometimes the science press or even the popular media catch wind of [...]
Posted in Impact: Proteomics Also tagged amino acids, biochemistry, configuration, Lu, Luo, protein, protein folding, proteomics, quantum folding, quantum mechanics, quantum transition Leave a comment
Reprogramming cells: The post stem cell future?
Sixth in a series of posts inspired by ten topics in ‘Insights of the Decade’ from the December 17, 2010 special issue of Science Magazine The topics are: Inflammation, climatology, tricks of light, alien planets, the microbiome, cell reprogramming, Martian water, the DNA time machine, cosmology and epigenetics. The original articles are now behind a [...]
Posted in Impact: Stem Cells Also tagged cell biology, cell reprogramming, embryonic stem cells, epigenetics, genetic modification, genetics, Gurdon, iPSC, pluripotent, proteomics, stem cells, Yamanaka Leave a comment
Oh Daphnia, why so many genes?
Ms. Water flea, Daphnia pulex…..credit: Wiki Commons This equal sign, =, is about as big the known champion of the gene-filled genome. Little Daphnia pulex, variously labeled a crustacean (like shrimp) or ‘the water flea,’ is the first of its subphylum to have its genome sequenced. Lo and behold: Daphnia’s genome has more genes – [...]
Posted in Impact: DNA Decoding Also tagged cloning, copy number variation, Daphnia, Environmental Genomics, gene-pool, genetics, genome, phenotype, water flea Leave a comment
Hoogsteen base pairs: An alternate structure in DNA
Reverse Hoogsteen base pairing…..Wikipedia Commons I know some of my biases. One of them is knee-jerk skepticism about taking little-tested scientific results and blowing them up to “…a cure for cancer” or “…revolutionize the electronics industry.” However, like most people I also have a bias to be curious about interesting, if somewhat unusual scientific findings. [...]
Posted in Impact: DNA Decoding Also tagged base pairs, biochemistry, double-helix, epigenetics, genetic coding, genetics, histones, Hoogsteen, NMR, proteins, RNA 3 Comments
Epigenetics ‘leaks’ into trans-generational inheritance